| Project/Area Number |
22791292
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kumamoto University (2010, 2012)
Kyushu University (2011) |
|---|
Principal Investigator |
MASUDA Toshiro 熊本大学, 医学部附属病院, 非常勤診療医師 (50551256)
|
|---|
| Research Collaborator |
MIMA Kousuke 熊本大学, 医学部附属病院, 非常勤医師 (00546559)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 肝細胞癌 / CD90 / EpCAM / CD44 / 血中癌細胞 / 癌幹細胞 / Side population cell / FACS |
|---|
| Research Abstract |
Evaluating in 17 healthy volunteers and 36 hepatocellular carcinoma patients, FACS withthe markers of CD44, CD90, and EpCAM revealed that the proportion of CD90+ / CD45- cellswere higher in the patients of hepatocellular carcinoma, especially in Stage III / IVcases. With in vitro studies, six hepatocellular carcinoma cell lines expressed any twoof cancer stem cell markers such as CD90, CD133, CD44, EpCAM, and CD13
|
