Identification of biomarkers related to invasion for pancreatic cancer by expression profile

• Project/Area Number: 22791297
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: HIRONO Seiko 和歌山県立医科大学, 医学部, 学内助教 (60468288)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 膵臓外科学

Research Abstract

MUC16 and mesothelin are involved in pancreatic cancer cell invasion and migration, and MUC16 and mesothelin clinically represent new prognostic biomarkers for PDAC and might be new therapeutic targets for patients with PDAC.

Research Products

• [Journal Article] Coexpression of MUC16 and mesothelin is related to the invasion process in pancreatic ductal adenocarcinoma (2012)
  • Author(s): Shimizu A, Hirono S, Tani M, Kawai M, Okada K, Miyazawa M, Kitahata Y, Nakamura Y, Noda T, Yokoyama S, Yamaue H
  • Journal Title: Cancer Sci Volume: 103 Pages: 739-746
  • Peer Reviewed
• [Presentation] 網羅的遺伝子発現解析を用いた膵癌の"invasion process"に関与する遺伝子の同定-MUC16とmesothelinの役割 (2012)
  • Author(s): 廣野誠子, 清水敦史, 横山省三, 谷眞至, 川井学, 岡田健一, 宮澤基樹, 北畑祐司, 中村靖司, 山上裕機
  • Organizer: 第31回日本分子腫瘍マーカー研究会
  • Place of Presentation: 名古屋
• [Presentation] 網羅的遺伝子発現解析を用いた膵癌における浸潤過程関連遺伝子群の同定による新規治療法の開発 (2012)
  • Author(s): 廣野誠子、清水敦史、谷眞至、川井学、岡田健一、宮澤基樹、北畑祐司、横山省三、山上裕機
  • Organizer: 第112回日本外科学会
  • Place of Presentation: 千葉
• [Presentation] Identification of biomarkera related to infiltrative process in pancreatic cancer (2010)
  • Author(s): 清水敦史、廣野誠子
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23