Clinical significance of IL-8 receptor expression in esophageal squamous cell carcinoma
| Project/Area Number |
22791301
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 食道外科学 / 食道癌 / IL-8 / 外科 / CXCR2 |
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| Research Abstract |
We validate the effect of CXCR2, IL-8 receptor, expression and postoperative complications on long-term prognosis in esophageal squamous cell carcinoma(ESCC) using resected specimens and cancer cell lines. In immunohistochemical investigation, CXCR2 was expressed in 33 specimens of 82. The patients with CXCR2 expression in primary tumor had poorer prognosis compared to those with negative expression. Especially, the patients with CXCR2 expression who suffered postoperative complications had quite a poor prognosis. The proliferative ability was accelerated by exposure of IL-8 in the human ESCC cell line which expresses CXCR2 strongly in vivo and in vitro. Our results suggest that the expression of CXCR2 is associated with the proliferation of ESCC. The patients with IL-8 receptor expression who suffered postoperative complications probably need strict follow-up and aggressive adjuvant therapy.
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Report
(3 results)
Research Products
(14 results)
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[Presentation] 食道扁平上皮癌におけるIL-8 receptor発現及び周術期合併症が予後に与える影響2011
Author(s)
西知彦, 竹内裕也, 松田祐子, 入野誠之, 才川義朗, 大山隆史, 尾曲健司, 迫裕之, 新原正大, 平野佑樹, 上田政和, 北川雄光
Organizer
第111回日本外科学会定期学術集会
Place of Presentation
(紙上開催)
Year and Date
2011-05-25
Related Report
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