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Clinical significance of IL-8 receptor expression in esophageal squamous cell carcinoma

Research Project

Project/Area Number 22791301
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKeio University

Principal Investigator

NISHI Tomohiko  慶應義塾大学, 医学部, 助教 (70445386)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords食道外科学 / 食道癌 / IL-8 / 外科 / CXCR2
Research Abstract

We validate the effect of CXCR2, IL-8 receptor, expression and postoperative complications on long-term prognosis in esophageal squamous cell carcinoma(ESCC) using resected specimens and cancer cell lines. In immunohistochemical investigation, CXCR2 was expressed in 33 specimens of 82. The patients with CXCR2 expression in primary tumor had poorer prognosis compared to those with negative expression. Especially, the patients with CXCR2 expression who suffered postoperative complications had quite a poor prognosis. The proliferative ability was accelerated by exposure of IL-8 in the human ESCC cell line which expresses CXCR2 strongly in vivo and in vitro. Our results suggest that the expression of CXCR2 is associated with the proliferation of ESCC. The patients with IL-8 receptor expression who suffered postoperative complications probably need strict follow-up and aggressive adjuvant therapy.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010

All Presentation (14 results)

  • [Presentation] IL-8 receptor expression in esophageal squamous cell carcinoma is associated with adverse prognosis2011

    • Author(s)
      西知彦
    • Organizer
      8^<th> International Symposium on Minimal Residual Cancer
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-8 receptor expression in esophageal squamous cell carcinoma is associated with adverse prognosis2011

    • Author(s)
      Nishi T
    • Organizer
      8^<th> International Symposium on Minimal Residual Cancer
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食道扁平上皮癌におけるIL-8 receptor発現及び周術期合併症が予後に与える影響2011

    • Author(s)
      西知彦
    • Organizer
      第111回日本外科学会定期学術集会
    • Year and Date
      2011-05-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 食道扁平上皮癌におけるIL-8 receptor発現及び周術期合併症が予後に与える影響2011

    • Author(s)
      西知彦, 竹内裕也, 松田祐子, 入野誠之, 才川義朗, 大山隆史, 尾曲健司, 迫裕之, 新原正大, 平野佑樹, 上田政和, 北川雄光
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      (紙上開催)
    • Year and Date
      2011-05-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Clinical significance of IL-8 receptor expression in esophageal squamous cell carcinoma2011

    • Author(s)
      西知彦
    • Organizer
      American Association for Cancer Research Annual Meeting 2011
    • Place of Presentation
      フロリダ州オーランド
    • Year and Date
      2011-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical significance of IL-8 receptor expression in esophageal squamous cell carcinoma2011

    • Author(s)
      Nishi T, Takeuchi H, Matsuda S, Irino T, Ueda M, Saikawa Y, Kitagawa Y
    • Organizer
      American Association for Cancer Research Annual Meeting 2011
    • Place of Presentation
      Florida, USA
    • Year and Date
      2011-04-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食道扁平上皮癌におけるIL-8 receptor発現及び周術期合併症と予後の相関2010

    • Author(s)
      西知彦
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2010-10-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 食道扁平上皮癌におけるIL-8 receptor発現及び周術期合併症と予後の相関2010

    • Author(s)
      西知彦
    • Organizer
      第48回 日本癌治療学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Clinical significance of IL-8 receptor expression in esophageal squamous cell carcinoma2010

    • Author(s)
      西知彦
    • Organizer
      第69回日本癌学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical significance of IL-8 receptor expression in esophageal squamous cell carcinoma2010

    • Author(s)
      西知彦
    • Organizer
      第69回 日本癌学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道扁平上皮癌細胞株を用いたIL-8 receptor発現と増殖能の解析2010

    • Author(s)
      西知彦
    • Organizer
      第64回日本食道学会学術集会
    • Place of Presentation
      石橋文化ホール
    • Year and Date
      2010-08-31
    • Related Report
      2011 Final Research Report
  • [Presentation] 食道扁平上皮癌細胞株を用いたIL-8 receptor発現と増殖能の解析2010

    • Author(s)
      西知彦
    • Organizer
      第64回 日本食道学会学術集会
    • Place of Presentation
      石橋文化ホール
    • Year and Date
      2010-08-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道扁平上皮癌におけるIL-8 receptor発現の臨床的意義2010

    • Author(s)
      西知彦
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-04-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 食道扁平上皮癌におけるIL-8 receptor発現の臨床的意義2010

    • Author(s)
      西知彦
    • Organizer
      第110回 日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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