A novel prevention method against re-obstruction of titanium alloy stent for biliary malignancy using hyperthermia with temperature controllable system.

• Project/Area Number: 22791303
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Keio University
• Principal Investigator: FUJISAKI Hiroto 慶應義塾大学, 医学部, 助教 (70464956)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ステント / 温熱療法 / 温度制御 / センサー / 高周波磁界

Research Abstract

Palliative biliary drainage using a metallic stent is performed for biliary obstruction by unresectable biliary carcinoma. The most important problem of biliary stenting therapy is re-obstruction due to tumor ingrowth. In this study, we used a detached temperature sensor with a magnetic-wave device. A titanium alloy stent was able to generate enough temperature when it was excited by 900kHz magnetic-wave device, however, the experiment could not reach to the stage to test connected sensor and magnetic-wave device in vivo.