Establishment of a novel spinal cooling method via a pleural cavity for spinal cord protection during thoracoabdominal aneurysm repair.

• Project/Area Number: 22791306
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Tohoku University
• Principal Investigator: TAKAHASHI Goro 東北大学, 大学院・医学系研究科, 非常勤講師 (50526449)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 脊髄冷却 / 対麻痺予防 / 胸腔内冷却 / ペルチェ素子 / 胸腔内脊髄冷却法 / 術中冷却装置 / 胸腹部大動脈瘤 / 対麻痺 / 胸腔内からの脊髄保護法

Research Abstract

(1) By the simulation system we have established, we found that it was possible to cool a spinal cord to the target temperature (systemic temperature - 5℃) within 15 to 20 minutes in the constant heat flux condition.
(2) We have developed the cooling device with peltier element.
(3) With porcine experimental model, we could cool spinal cord to - 2.7℃ compared with systemic temperature within 15minutes in condition with aortic clamping and thermal insulation of a back.