Anti-tumor effects of autophagy induction in malignant pleural mesothelioma.

Research Project

Project/Area Number	22791321
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Thoracic surgery
Research Institution	Keio University
Principal Investigator	ASAKURA Keisuke 慶應義塾大学, 医学部, 共同研究員 (90383786)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	悪性胸膜中皮腫 / スタチン / オートファジー
Research Abstract	Malignant pleural mesothelioma is widely resistant to therapies, and new treatment starategies are needed. Recent reports have indicated the potential efficacy of statins against malignant pleural mesothelioma cells in vitro. Here we show that lovastatin reduces primary tumor and metastasis in a mouse model of human malignant pleural mesothelioma, and that induction of autophagic changes may at least in part be involved in this process.

Report

(3 results)