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Anti-tumor effects of autophagy induction in malignant pleural mesothelioma.

Research Project

Project/Area Number 22791321
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionKeio University

Principal Investigator

ASAKURA Keisuke  慶應義塾大学, 医学部, 共同研究員 (90383786)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords悪性胸膜中皮腫 / スタチン / オートファジー
Research Abstract

Malignant pleural mesothelioma is widely resistant to therapies, and new treatment starategies are needed. Recent reports have indicated the potential efficacy of statins against malignant pleural mesothelioma cells in vitro. Here we show that lovastatin reduces primary tumor and metastasis in a mouse model of human malignant pleural mesothelioma, and that induction of autophagic changes may at least in part be involved in this process.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2011

All Journal Article (4 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] The cytostatic effects of lovastatin on ACC-MESO-1 cells2011

    • Author(s)
      Asakura K, Izumi Y, Yamamoto M, Yamauchi Y, Kawai K, Serizawa A, Mizushima T, Ohmura M, Kawamura M, Wakui M, Adachi T, Nakamura M, Suematsu M, Nomori H
    • Journal Title

      J Surg Res

      Volume: 170(2)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells2011

    • Author(s)
      Yamauchi Y, Izumi Y, Asakura K, Fukutomi T, Serizawa A, Kawai K, Wakui M, Suematsu M, Nomori H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410(2) Pages: 328-32

    • Related Report
      2011 Final Research Report
  • [Journal Article] The cytostatic effects of lovastatin on ACC-MESO-1 cells2011

    • Author(s)
      Asakura K
    • Journal Title

      Journal of Surgical Research

      Volume: 170 Pages: 197-209

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells2011

    • Author(s)
      Yamauchi Y, Asakura K
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 410 Pages: 328-332

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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