The effect of combined treatment with Impella(R) and landiolol in a swine model of ST-elevation myocardial infarction

• Project/Area Number: 22791324
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Nihon University
• Principal Investigator: YOSHITAKE Isamu 日本大学, 医学部, 助手 (60409034)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 心臓大血管外科学 / 循環器・高血圧 / 外科

Research Abstract

We have developed a new approach named hibernation therapy(HT) for complete revascularization in the early stage of STEMI using aβ-blocker(landiolol) and an Impella [○! R] left ventricular assist device, and verified the effect of this therapy in a swine model. HT at the early stage in STEMI stabilized the hemodynamic conditions and reduced infarct size and complications in a swine model. These results suggest that HT can improve the prognosis of patients with STEMI.

Research Products

• [Journal Article] The Effect of Combined Treatment with Impella(R) and Landiolol in a Swine Model of Acute Myocardial Infarction
  • Author(s): Yoshitake I, Hata M, Sezai A, Unosawa S, Wakui S, Kimura H, Nakata K, Hata H, Shiono M
  • Journal Title: Journal of Artificial Organs Volume: (in press)
  • NAID: 10031056069
  • Peer Reviewed
• [Journal Article] The Effect of Combined Treatment with Impella^[○!R] and Landiolol in a Swine Model of Acute Myocardial Infarction
  • Author(s): Yoshitake I
  • Journal Title: Journal of Artificial Organs Volume: (掲載確定)(印刷中)
  • NAID: 10031056069
  • Peer Reviewed
• [Presentation] Effect of Combined Therapy Used by Landiolol and Impella(R) in a Swine Model of Myocardial Infarction (2012)
  • Author(s): Yoshitake I, Hata M, Sezai A, Kimura H, Takahashi K, Nakata K, Hiroaki H, Shiono M
  • Organizer: The Asian Society for Cardiovascular & Thoracic Surgery 20th Annual Meeting
  • Place of Presentation: バリインターナショナルコンベンションセンター(インドネシア)
  • Year and Date: 2012-03-11
• [Presentation] Effect of Combined Therapy Used by Landiolol and Impella^[○!R] in a Swine Model of Myocardial Infarction (2012)
  • Author(s): Yoshitake I
  • Organizer: The Asian Society for Cardiovascular & Thoracic Surgery 20th Annual Meeting
  • Place of Presentation: バリインターナショナルコンベンションセンター(インドネシア)
  • Year and Date: 2012-03-11
• [Presentation] 急性心筋梗塞(STEMI)モデルにおけるβ-blockerおよびimpella(R)を用いたHibernation therapy(HT)の有効性について (2011)
  • Author(s): 吉武勇、中田金一、秦光賢、瀬在明、宇野澤聡、和久井真司、木村玄、高橋佳奈、畑博明、塩野元美
  • Organizer: 第64回日本胸部外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-10
• [Presentation] 急性心筋梗塞(STEMI)モデルにおけるβ-blockerおよびimpella^[○!R]を用いたHibernation therapy (HT)の有効性について (2011)
  • Author(s): 吉武勇
  • Organizer: 第64回日本胸部外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-10
• [Presentation] Effect of Hibernation Therapy Used by Landiolol and Impella(R) in a Swine Model of Acute Myocardial Infarction (2011)
  • Author(s): 吉武勇、秦光賢、瀬在明、飯田充、宇野澤聡、高山忠輝、塩野元美
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-08-04
• [Presentation] Effect of Hibernation Therapy Used by Landiolol and Impella^[○!R] in a Swine Model of Acute Myocardial Infarction (2011)
  • Author(s): 吉武勇
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-08-04