| Project/Area Number |
22791325
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肺腺癌 / アクアポリン1 / ヒストン修飾 / 術後転移 / 転移 / HIF-1α / 肺癌 / 浸潤 / 培養細胞 / CEA / p53 / Ki67 |
|---|
| Research Abstract |
About the expression mechanism of aquaporin(AQP) 1, we studied to the histone modification of the epigenetics mechanism. AQP1 was not associated with histone modification directly. However, a postoperative recurrence and a stage and cell differentiation of lung cancer were associated with dimethylated histone3 lysine4(H3K4dime) which was histone modification one. H3K4dime was associated with HIF-1, too. H3K4dime is associated with extension and the grade of the lung cancer, and is important as a prognostic factor of lung cancer.
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