Nuclear Morphometry for Cytologic Diagnosis in Adenocarcinoma of the Lung
| Project/Area Number |
22791327
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Dokkyo Medical University (2011)
Gunma Institute of Public Health and Environmental Sciences (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 呼吸器外科学 / 肺腺癌 / 核グレード / 細胞診 / EGFR / k-ras |
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| Research Abstract |
The nuclear area of tumor cells(119.1um^2±64.4) in adenocarcinoma of the lung was significantly larger than that of normal cells(67.1um^2±17.8)(P<0.05). The ROC curve analysis showed that an NA cut-off level of 81.0um^2 had a sensitivity of 80% and specificity of 86% to detect malignant strictures. The nuclear area of tumor cells in EGFR mutant type(92.5um^2±19.6) was significantly smallar than that of tumor cells in EGFR wild type(125.3um^2±69.5)(P<0.05).
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Report
(3 results)
Research Products
(6 results)
