| Project/Area Number |
22791335
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Niigata University |
|---|
Principal Investigator |
YAJIMA Naoki 新潟大学, 医歯学総合病院, 特任助教 (10572159)
|
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| Co-Investigator(Renkei-kenkyūsha) |
AOKI Hiroshi 新潟大学, 脳研究所, 助教 (30515771)
|
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | オートファジー / モニタリング / 悪性神経膠腫 / 神経膠腫 / グリオーマ / リアルタイムモニタリング / タイムラプス / アポトーシス / ユビキチン |
|---|
| Research Abstract |
It has been shown that autophagy is induced by various chemotherapeutic drugs including Temozolomide, which is the standard treatment for malignant gliomas. Moreover, the serial induction of autophagy after the medical treatment, which was not clear, will be elucidated by employing time-lapse imaging. Data of combination treatment with autophagy inhibitors were obtained. These data can become very important information when verifying effective combinations and timing of treatments in vitro.
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