Genetic alteration of pediatric astrocytic tumors associated with malignant transformation

• Project/Area Number: 22791337
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Kanazawa University
• Principal Investigator: KITA Daisuke 金沢大学, 附属病院, 助教 (10377385)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 小児脳腫瘍 / 星細胞腫 / 遺伝子変異 / 悪性化機構 / 悪性星細胞腫 / 家族性脳腫瘍 / 自己免疫性リンパ球増殖症 / FAS遺伝子 / TP53遺伝子 / シグナル伝達経路 / 腫瘍内出血 / 毛様星細胞腫 / IDH-1変異 / sphingosine-1-phosphate receptor type 1 / 5-ALA / RNAi / 水頭症 / BRAF

Research Abstract

We assessed the relationship between histology and genetic alteration of pilocytic astrocytomas, and found there were strong correlation between BRAF gene alteration and histological accuracy. We then researched a tumor which had been diagnosed as pilocytic astrocytoma. We re-diagnosed it as anaplastic astrocytoma and found that the tumor could be associated with concomitant mutations of FAS and TP53, and it might progress secondarily from the long-standing diffuse astrocytoma via uncommon genetic alterations.

Research Products

• [Journal Article] Postoperative diabetes insipidusassociated with pituitary apoplexy duringpregnancy (2012)
  • Author(s): Kita, D., Hayashi Y, Sano H, Takamura T, Hayashi Y, Tachibana O, Hamada J
  • Journal Title: Neuroendocrinol Lett Volume: (in press)
  • Peer Reviewed
• [Journal Article] The expression level ofsphingosine-1-phosphate receptor type 1 isrelated to MIB-1 labeling index andpredicts survival of glioblastoma patients (2012)
  • Author(s): Yoshida, Y., Nakada, M., Harada, T., Tanaka, S., Furuta, T., Hayashi, Y., Kita, D., Uchiyama, N. and Hamada, J.
  • Journal Title: J Neurooncol Volume: 98 Issue: 1 Pages: 41-7
  • DOI: 10.1007/s11060-009-0064-5
  • Peer Reviewed
• [Journal Article] Postoperative diabetes insipidus associated with pituitary apoplexy during pregnancy (2012)
  • Author(s): Kita D, Hayashi Y, Sano H, Takamura T, Hayashi Y, Tachibana O, Hamada J
  • Journal Title: Neuroendocrinology Letters Volume: (in press)
  • Peer Reviewed
• [Journal Article] Secondary anaplastic astrocytomadeveloping in a young adult withautoimmune lymphoproliferativesyndrome(ALPS) (2011)
  • Author(s): Kita, D., Hayashi, Y., Watanabe, T., Korshunov, A., von Deimling, A., Nakada, M., Kasahara, Y., Zen, Y. and Hamada, J
  • Journal Title: Neuropathol ApplNeurobiol Volume: 37 Issue: 4 Pages: 423-7
  • DOI: 10.1111/j.1365-2990.2010.01123.x
  • Peer Reviewed
• [Journal Article] Thecorrelation between promoter methylationstatus and the expression level ofO6-methylguanine-DNA (2011)
  • Author(s): Suzuki, T., Nakada, M., Yoshida, Y., Nambu, E., Furuyama, N., Kita, D., Hayashi, Y. and Hamada, J.
  • Journal Title: Jpn J Clin Oncol Volume: 41 Issue: 2 Pages: 190-6
  • DOI: 10.1093/jjco/hyq224
  • Peer Reviewed
• [Journal Article] Aberrant SignalingPathways in Glioma (2011)
  • Author(s): Nakada, M., Kita, D., Watanabe, T., Hayashi, Y., Teng, L., Pyko, I. V. andHamada, J.
  • Journal Title: Cancers Volume: 3 Issue: 3 Pages: 3242-78
  • DOI: 10.3390/cancers3033242
  • Peer Reviewed
• [Journal Article] Recurrent anaplastic meningioma treatedby sunitinib based on results fromquantitative proteomics (2011)
  • Author(s): Yoshikawa, A., Nakada, M., Ohtsuki, S., Hayashi, Y., Obuchi, W., Sato, Y., Ikeda, C., Watanabe, T., Kawahara, Y., Hasegawa, T., Sabit, H., Kita, D., Nakanuma, Y., Terasaki, T. and Hamada, J.
  • Journal Title: NeuropatholAppl Neurobiol Volume: 38 Issue: 1 Pages: 105-10
  • DOI: 10.1111/j.1365-2990.2011.01197.x
  • Peer Reviewed
• [Journal Article] Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with survival of patients with glioblastoma (2010)
  • Author(s): Yoshida Y, Nakada M, Sugimoto N, Harada T, Hayashi Y, Kita D, Uchiyama N, Hayashi Y, Yachie A, Takuwa Y, Hamada JI.
  • Journal Title: Int J Cancer Volume: 126(10) Issue: 10 Pages: 2341-2352
  • DOI: 10.1002/ijc.24933
  • Peer Reviewed
• [Journal Article] Implication of 5-aminolevulinic acid fluorescence of the ventricular wall for postoperative communicating hydrocephalus associated with cerebrospinal fluid dissemination in patients with glioblastoma multiforme : a report of 7 cases (2010)
  • Author(s): Hayashi, Y., Nakada, M., Tanaka, S., Uchiyama, N., Kita, D. and Hamada, J
  • Journal Title: J Neurosurg Volume: 112(5) Issue: 5 Pages: 1015-19
  • DOI: 10.3171/2009.8.jns09516
  • Peer Reviewed
• [Journal Article] RNAi in Malignant BrainTumors (2010)
  • Author(s): Nakada, M., Kita, D., Hayashi, Y., Kawasaki, K., Hamada, J. and Minamoto, T
  • Journal Title: Relevance to Molecular and Translational Research RNA Technologies and Their Applications Pages: 107-129
  • DOI: 10.1007/978-3-642-12168-5_5
  • ISBN: 9783642121678, 9783642121685
  • Peer Reviewed
• [Journal Article] Scrotal Migration of the Peritoneal Catheter of a Ventriculoperitoneal Shunt in a 5-Year-Old Male -Case Report- (2010)
  • Author(s): Kita. D., Y. Hayashi, M. Kinoshita, K. Ohama and J. Hamada.
  • Journal Title: Neurologia medico-chirurgica Volume: 50 Issue: 12 Pages: 1122-1125
  • DOI: 10.2176/nmc.50.1122
  • NAID: 10027124053
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed
• [Journal Article] Implication of 5-aminolevulinic acid fluorescence of the ventricular wall for postoperative communicating hydrocephalus associated with cerebrospinal fluid dissemination in patients with glioblastoma multiforme : a report of 7 cases. (2010)
  • Author(s): Y.Hayashi, M.Nakada, S.Tanaka, N.Uchiyama, D.Kita, J.Hamada
  • Journal Title: Journal of Neurosurgery Volume: 112 Pages: 1015-1019
  • Peer Reviewed
• [Journal Article] Scrotal migration of the peritoneal catheter of a ventriculoperitoneal shunt in a 5-year-old male. Case report. (2010)
  • Author(s): D.Kita, Y.Hayashi, M.Kinoshita, K.Ohama, J.Hamada
  • Journal Title: Neurologica Medico-Chirugica Volume: 50 Pages: 1122-1125
  • NAID: 10027124053
  • Peer Reviewed
• [Journal Article] The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients. (2010)
  • Author(s): Y.Yoshida, M.Nakada, T.Harada, S.Tanaka, T.Furuta, Y.Hayashi, D.Kita, N.Uchiyama, J.Hamada
  • Journal Title: Journal of Neurooncology Volume: 98 Pages: 41-47
  • Peer Reviewed
• [Journal Article] Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival. (2010)
  • Author(s): Y.Yoshida, M.Nakada, N.Sugimoto, T.Harada, Y.Hayashi, D.Kita, N.Uchiyama, A.Yachie, Y.Takuwa, J.Hamada
  • Journal Title: International Journal of Cancer Volume: 126 Pages: 2341-2352
  • Peer Reviewed
• [Journal Article] RNAi in Malignant Brain Tumors : Relevance to Molecular and Translational Research. (2010)
  • Author(s): M.Nakada, D.Kita, Y.Hayashi, K.Kawasaki, J.Hamada, T.Minamoto
  • Journal Title: RNA Technologies and Their Applications (Springer) Pages: 107-129
• [Presentation] 異所性下垂体腫瘍の3例 (2012)
  • Author(s): 喜多大輔、林康彦、立花修、笹川泰生、林裕、濱田潤一郎
  • Organizer: 第22回日本間脳下垂体腫瘍学会
  • Place of Presentation: 東京ステーションコンファレンス(東京)
  • Year and Date: 2012-02-24
• [Presentation] 化学療法後に中脳水道狭窄を発症した水頭症の1例 (2012)
  • Author(s): 喜多大輔、林康彦、北林朋宏、木下雅史、濱田潤一郎
  • Organizer: 第12回日本正常圧水頭症研究会
  • Place of Presentation: セルレーン大阪(大阪)
  • Year and Date: 2012-02-11
• [Presentation] 治療に難渋した脳室内出血の1例 (2011)
  • Author(s): 喜多大輔、林康彦、濱田潤一郎
  • Organizer: 第1回中部神経内視鏡フォーラム
  • Place of Presentation: 名古屋(ウインクあいち)
  • Year and Date: 2011-09-24
• [Presentation] 治療に難渋した脳室内出血の1例 (2011)
  • Author(s): 喜多大輔、林康彦、濱田潤一郎
  • Organizer: 第1回中部神経内視鏡勉強会
  • Place of Presentation: 福井(国民宿舎鷹巣荘)
  • Year and Date: 2011-09-16
• [Presentation] 発症4カ月後の摘出術で眼球運動障害が改善した下垂体腫瘍の1例 (2011)
  • Author(s): 喜多大輔、林康彦、木下雅史、北林朋宏、立花修、濱田潤一郎
  • Organizer: 第17回北陸間脳下垂体研究会
  • Place of Presentation: 福井(メルパルク福井)
  • Year and Date: 2011-08-27
• [Presentation] 発症4ヵ月後の摘出術で眼球運動障害が改善した下垂体腫瘍 (2011)
  • Author(s): 喜多大輔、林康彦、木下雅史、北林朋宏、立花修、廣田潤一郎
  • Organizer: 第17回北陸間脳下垂体研究会
  • Place of Presentation: メルパルク福井(福井)
  • Year and Date: 2011-08-27
• [Presentation] 急性水頭症を伴う脳室内出血に対する治療 (2011)
  • Author(s): 喜多大輔、林康彦、濱田潤一郎
  • Organizer: 急性水頭症を伴う脳室内出血に対する治療
  • Place of Presentation: 京都(京都府立大学)
  • Year and Date: 2011-08-07
• [Presentation] 急性水頭症を伴う脳室内出血に対する治療 (2011)
  • Author(s): 喜多大輔、林康彦、濱田潤一郎
  • Organizer: 京都髄液フォーラム'23
  • Place of Presentation: 京都府立医科大学(京都)
  • Year and Date: 2011-08-07
• [Presentation] Treatment options and complications of hydrocephalus (2011)
  • Author(s): D.Kita, Y.Hayashi, J.Hamada
  • Organizer: 6th Japan-Russia Workshop on Neuroscience
  • Place of Presentation: クラスノヤルスク医科大学(クラスノヤルスク、ロシア)
  • Year and Date: 2011-07-04
• [Presentation] 水頭症手術の治療戦略 (2011)
  • Author(s): 喜多大輔、林康彦、濱田潤一郎
  • Organizer: 第1回石川CSFフォーラム
  • Place of Presentation: マンテンホテル金沢(石川)
  • Year and Date: 2011-07-01
• [Presentation] 妊娠中に下垂体卒中を呈した非機能性下垂体腺腫の1例 (2011)
  • Author(s): 喜多大輔、林康彦、佐野宏樹、濱田潤一郎、加藤健一郎、篁俊成、若松弘一、立花修
  • Organizer: 第21回日本間脳下垂体腫瘍学会
  • Place of Presentation: 東京(秋葉原コンベンションホール)
  • Year and Date: 2011-03-11
• [Presentation] 妊娠中に下垂体卒中を呈した非機能性下垂体腺腫の1例 (2011)
  • Author(s): 喜多大輔、林康彦、古田拓也、濱田潤一郎、山崎法明、宇野英一、荒川泰明、橋本正明
  • Organizer: 第21回日本肝脳下垂体腫瘍学会
  • Place of Presentation: 秋葉原コンベンションホール(東京)
  • Year and Date: 2011-03-11
• [Presentation] 内視鏡的第3脳室底開窓術を行ったPersistent Blake's Pouch Cystの4例 (2011)
  • Author(s): 喜多大輔、林康彦、古田拓也、濱田潤一郎、山崎法明、宇野英一、荒川泰明、橋本正明
  • Organizer: 第11回日本正常圧水頭症研究会
  • Place of Presentation: 千歳(ANAクラウンプラザ千歳)
  • Year and Date: 2011-02-12
• [Presentation] 内視鏡的第3脳室底開窓術を行ったPersistent Blake's Pouch Cystの4例 (2011)
  • Author(s): 喜多大輔、林康彦、古田拓也、濱田潤一郎、山崎法明、宇野英一、荒川泰明、橋本正明
  • Organizer: 第11回日本正常圧水頭症研究会
  • Place of Presentation: クラウンプラザホテル千歳(北海道)
  • Year and Date: 2011-02-12
• [Presentation] 蝶形骨洞内の正中同定に関わる構造の検討 (2011)
  • Author(s): 喜多大輔、林康彦、岩戸雅之、林裕、立花修、濱田潤一郎
  • Organizer: 蝶形骨洞内の正中同定に関わる構造の検討
  • Place of Presentation: 横浜(パシフィコ横浜)
• [Presentation] Treatment options and complications of hydrocephalus (2011)
  • Author(s): D. Kita, Y. Hayashi, J. Hamada
  • Organizer: 6th Japan-Russia Workshop on Neuroscience
  • Place of Presentation: Krasnoyarsk, Russia(Krasnoyarsk Medical University)
• [Presentation] 下垂体腫瘍手術時の蝶形骨洞内の正中同定に関わる構造の検討 (2011)
  • Author(s): 喜多大輔、林康彦、岩戸雅之、林裕、立花修、濱田潤一郎
  • Organizer: 第70回日本脳神経外科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
• [Presentation] 脳室内出血に対し内視鏡的血腫除去を行った7例の検討 (2010)
  • Author(s): 喜多大輔、林康彦、内山尚之、林裕、濱田潤一郎、岩戸雅之、東壮太郎、廣田雄一、池田正人
  • Organizer: 第17回日本神経内視鏡学会
  • Place of Presentation: 千葉(幕張メッセ)
  • Year and Date: 2010-12-10
• [Presentation] 脳室内出血に対し内視鏡的血腫除去を行った7例の検討 (2010)
  • Author(s): 喜多大輔、林康彦、内山尚之、林裕、濱田潤一郎、岩戸雅之、東壮太郎、廣田雄一、池田正人
  • Organizer: 第17回日本神経内視鏡学会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2010-12-10
• [Presentation] Secondary anaplastic astrocytomadeveloping in a young adult withautoimmune lymphoproliferative syndrome(ALPS) (2010)
  • Author(s): 喜多大輔、林裕、林康彦、中田光俊、渡辺卓也、Andrey Korshunov、Andreas vonDeimling、全陽、笠原善仁、濱田潤一郎
  • Organizer: 第28回日本脳腫瘍学会
  • Place of Presentation: 軽井沢(軽井沢プリンスホテル)
  • Year and Date: 2010-11-28
• [Presentation] Secondary anaplastic astrocytoma developing in a young adult with autoimmune lymphoproliferative syndrome (ALPS) (2010)
  • Author(s): 喜多大輔、林裕、林康彦、中田光俊、渡辺卓也、Andrey Korshunov Andreas von Deimling、全陽、笠原善仁、濱田潤一郎
  • Organizer: 第28回日本脳腫瘍学会
  • Place of Presentation: 軽井沢プリンスホテル(長野県)
  • Year and Date: 2010-11-28
• [Presentation] 水頭症患者における透明中隔自然穿破に関わる因子の検討 (2010)
  • Author(s): 喜多大輔、林康彦、中田光俊、毛利正直、内山尚之、林裕、濱田潤一郎
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡(福岡国際会議場)
  • Year and Date: 2010-10-27
• [Presentation] 水頭症患者における透明中隔自然穿破に関わる因子の検討 (2010)
  • Author(s): 喜多大輔、林康彦、中田光俊、毛利正直、内山尚之、林裕、濱田潤一郎
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2010-10-27
• [Presentation] Secondary anaplastic astrocytomadeveloping in a young adult with autoimmune lymphoproliferative syndrome(ALPS) (2010)
  • Author(s): 喜多大輔、林裕、林康彦、中田光俊、渡辺卓也、Andrey Korshunov、Andreas vonDeimling、全陽、笠原善仁、濱田潤一郎
  • Organizer: Secondary anaplastic astrocytoma developing in a young adult with autoimmune lymphoproliferative syndrome(ALPS)
  • Place of Presentation: 大阪(大阪国際会議場)
  • Year and Date: 2010-09-23
• [Presentation] Secondary anaplastic astrocytoma developing in a young adult with autoimmune lymphoproliferative syndrome (ALPS) (2010)
  • Author(s): 喜多大輔、林裕、林康彦、中田光俊、渡辺卓也、Andrey Korshunov、Andreas von Deimling、全陽、笠原善仁、濱田潤一郎
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-23
• [Presentation] 妊娠中に下垂体卒中を呈した非機能性下垂体腺腫の1例 (2010)
  • Author(s): 喜多大輔、林康彦、佐野宏樹、濱田潤一郎、加藤健一郎、篁俊成、若松弘一、立花修
  • Organizer: 第16回北陸間脳下垂体研究会
  • Place of Presentation: 金沢(金沢都ホテル)
  • Year and Date: 2010-09-04
• [Presentation] 脳室腹腔シャントの陰嚢内迷入-自験例および報告例の検討ー (2010)
  • Author(s): 喜多大輔、林康彦、木下雅史、濱田潤一郎、小浜和憲
  • Organizer: 第38回日本小児脳神経外科学会
  • Place of Presentation: 富山(富山国際会議場)
  • Year and Date: 2010-06-04
• [Presentation] 脳室腹腔シャントの陰嚢内迷入-自験例および報告例の検討- (2010)
  • Author(s): 喜多大輔、林康彦、木下雅史、濱田潤一郎、小浜和憲
  • Organizer: 第38回日本小児脳神経外科学会
  • Place of Presentation: 富山国際会議場(富山県)
  • Year and Date: 2010-06-04
• [Remarks]
  • URL: http://kurt.kanazawa-u.ac.jp/souran_ku/info.php?teacher_id=2406.
• [Remarks]
  • URL: http://kurt.kanazawa-u.ac.jp/souran_ku/info.php?teacher_id=240
• [Remarks]
  • URL: http://kurt.kanazawa-u.ac.jp/souran_ku/info.php?teacher_id=240