Transplantation of multiple type of the cells derived from olfactory mucosa for the recovery of spinal cord injury
| Project/Area Number |
22791342
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 神経再生 / 脊髄損傷 / 神経前駆細胞 / 嗅神経鞘細胞 |
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| Research Abstract |
The olfactory mucosal cells(OMCs) contain neural progenitor cells(NPCs) and olfactory ensheathing cells(OECs), both of which have been reported to be effective in neuronal and axonal regeneration. We measured neurotrophins production of OMCs and revealed OMCs mainly produced NT-3 in this system. Because anti-neurotrophin antibody cocktail drastically reduced axon-promoting effects of the OMCs, NT-3 production is the key factor of axon-promoting effects of OMCs. Extending axons from cortex were mainly observed in OECs. Another possibility is that NPC in the OMCs matured to neurons. Neural cells constituted 14% of OMCs. We are now examining to identify the interaction between neurons from cotex and from OMCs.
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Report
(3 results)
Research Products
(17 results)
