Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Research Abstract |
Transforming growth factor-beta(TGF-b) is a kind of cytokines. It is associated with the growth and rupture of aortic artery aneurysms(AAA). TGF-b is thought to be as a promising therapeutic target against AAA, however its role on cerebral aneurysms remains obscure. Using our aneurismal model, we observed the up-regulation of TGF-b in the aneurismal wall and the enhancement of it by pharmacological treatment, suggesting that TGF-b may is a promising therapeutic target on cerebral aneurysms
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