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The role of TGF-βand approaches of new pharmacological treatments on cerebral aneurysm formation

Research Project

Project/Area Number 22791347
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionThe University of Tokushima

Principal Investigator

KANEMATSU Yasuhisa  徳島大学, 病院, 助教 (90363142)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords脳動脈瘤 / TGF-β
Research Abstract

Transforming growth factor-beta(TGF-b) is a kind of cytokines. It is associated with the growth and rupture of aortic artery aneurysms(AAA). TGF-b is thought to be as a promising therapeutic target against AAA, however its role on cerebral aneurysms remains obscure. Using our aneurismal model, we observed the up-regulation of TGF-b in the aneurismal wall and the enhancement of it by pharmacological treatment, suggesting that TGF-b may is a promising therapeutic target on cerebral aneurysms

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (4 results)

  • [Journal Article] A mouse model of intracranial aneurysm : technical considerations2011

    • Author(s)
      Tada Y, Kanematsu Y, Kanematsu M, Nuki Y, Liang EI, Wada K, Makino H, Hashimoto T
    • Journal Title

      Acta Neurochir Suppl

      Volume: 111 Pages: 31-5

    • DOI

      10.1007/978-3-7091-0693-8_6

    • ISBN
      9783709106921, 9783709106938
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical roles of macrophages in the formation of intracranial aneurysm2011

    • Author(s)
      Kanematsu Y, Kanematsu M, Kurihara C, Tada Y, Tsou TL, van Rooijen N, Lawton MT, Young WL, Liang EI, Nuki Y, Hashimoto T.
    • Journal Title

      Stroke

      Volume: 42 Issue: 1 Pages: 173-8

    • DOI

      10.1161/strokeaha.110.590976

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Statins promote the growth of experimentally induced cerebral aneurysms in estrogen-deficient rats2011

    • Author(s)
      Tada Y, Kitazato KT, Yagi K, Shimada K, Matsushita N, Kinouchi T, Kanematsu Y, Satomi J, Kageji T, Nagahiro S
    • Journal Title

      Stroke

      Volume: 42 Issue: 8 Pages: 2286-93

    • DOI

      10.1161/strokeaha.110.608034

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A mouse model of intracranial aneurysm : technical considerations2011

    • Author(s)
      Tada Y, et al
    • Journal Title

      Acta Neurochir Suppl

      Volume: 11 Pages: 31-35

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical roles of macrophages in the formation of intracranial aneurysm.2011

    • Author(s)
      Kanematsu Y, et al
    • Journal Title

      Stroke

      Volume: 42 Pages: 173-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacologically induced thoracic and abdominal aortic aneurysms in mice2010

    • Author(s)
      Kanematsu Y, Kanematsu M, Kurihara C, Tsou TL, Nuki Y, Liang EI, Makino H, Hashimoto T.
    • Journal Title

      Hypertension

      Volume: 55 Pages: 1267-74

    • Related Report
      2011 Final Research Report
  • [Journal Article] Pharmacologically induced thoracic and abdominal aortic aneurysms in mice.2010

    • Author(s)
      Kanematsu Y, et al
    • Journal Title

      Hypertension

      Volume: 55 Pages: 1267-74

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ACTIVATION OF NUCLEAR RECEPTORS ON NEUROPROTECTION AFTER EXPERIMENTAL CEREBRAL ISCHEMIA IN FEMALE RATS2012

    • Author(s)
      Kohrai M, Kitazato KT., Kinouchi T, Shimada K, Sumiyoshi M, Matsushita N, Kanematsu Y, Satomi J, Kageji T, Nagahiro S.
    • Organizer
      80^<th> AANS
    • Place of Presentation
      Miami, Florida
    • Related Report
      2011 Final Research Report
  • [Presentation] Excessive salt-intake exacerbates ischemic brain damage independent of blood pressure2012

    • Author(s)
      Sumiyoshi M, Kinouchi T, Tsutsumi T, Kitazato K, Shimada K, Matsushita N, Kanematsu Y, Satomi J, Nagahiro S.
    • Organizer
      80^<th> AANS
    • Place of Presentation
      Miami, Florida
    • Related Report
      2011 Final Research Report
  • [Presentation] Influence of sodium retention on the formation of cerebral aneurysm2012

    • Author(s)
      Matsushita N, Kitazato K, Shimada K, Kinouchi T, Kanematsu Y, Satomi J, Nagahiro S
    • Organizer
      80^<th> AANS
    • Place of Presentation
      Miami, Florida
    • Related Report
      2011 Final Research Report
  • [Presentation] High salt-intake under hypoestrogenicity exacerbates ischemic brain damage without affecting the blood pressure2011

    • Author(s)
      Sumiyoshi M, Kitazato KT, Kinouchi T, Tsutsumi T, Shimada K, Matsushita N, Kanematsu Y., Satomi J., Nagahiro S.
    • Organizer
      Brain & Pet
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Annual Research Report 2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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