The role of zinc in seizure-induced epileptogenesis
| Project/Area Number |
22791349
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | てんかん |
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| Research Abstract |
In the present study, we examined whether zinc effects on seizure-induced neurogenesis in mouse hippocampus, and determined whether zinc uptake is necessary for activation of microglia from which inflammatory mediators contribute to decrease in the threshold to seizures. Zinc pretreatment resulted in partially suppression of neurogenesis in the dentate gyrus of hippocampus, and protected mice from seizure-induced cognitive decline. Additionally, extracellular zinc was uptaken by microglia through zinc transporters and induced morphological changes characterized by activated microglia. These results suggest that zinc may be a important factor associated with epileptogenesis.
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Report
(3 results)
Research Products
(6 results)
