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The role of zinc in seizure-induced epileptogenesis

Research Project

Project/Area Number 22791349
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKochi University

Principal Investigator

HIGASHI Youichirou  高知大学, 教育研究部・医療学系, 助教 (80380062)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsてんかん
Research Abstract

In the present study, we examined whether zinc effects on seizure-induced neurogenesis in mouse hippocampus, and determined whether zinc uptake is necessary for activation of microglia from which inflammatory mediators contribute to decrease in the threshold to seizures. Zinc pretreatment resulted in partially suppression of neurogenesis in the dentate gyrus of hippocampus, and protected mice from seizure-induced cognitive decline. Additionally, extracellular zinc was uptaken by microglia through zinc transporters and induced morphological changes characterized by activated microglia. These results suggest that zinc may be a important factor associated with epileptogenesis.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Microglial zinc uptake via zinc transporters, induces ATP release and the activation of microglia2011

    • Author(s)
      Youichirou Higashi, Shohei Segawa, Takaaki Matsuo, Shogo Nakamura, Yukiko Kikkawa, Kentaro Nishida, Kazuki Nagasawa
    • Journal Title

      Glia

      Volume: 59 Pages: 1933-1945

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] てんかん発作による海馬歯状回神経新生異常に対する亜鉛投与の効果2011

    • Author(s)
      東洋一郎
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] てんかん発作による海馬歯状回神経新生異常に対する亜鉛投与の効果2011

    • Author(s)
      東洋一郎
    • Organizer
      日本薬学会第131年会
    • Year and Date
      2011-03-30
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] てんかん発作による海馬歯状回神経新生異常に対する亜鉛投与の効果2010

    • Author(s)
      東洋一郎
    • Organizer
      第44回日本てんかん学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県)
    • Year and Date
      2010-10-15
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] てんかん発作による海馬歯状回神経新生異常に対する亜鉛投与の効果2010

    • Author(s)
      東洋一郎
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report
  • [Presentation] てんかん発作による海馬歯状回神経新生異常に対する亜鉛投与の効果2010

    • Author(s)
      東洋一郎
    • Organizer
      第33回日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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