| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In the present study, we examined whether zinc effects on seizure-induced neurogenesis in mouse hippocampus, and determined whether zinc uptake is necessary for activation of microglia from which inflammatory mediators contribute to decrease in the threshold to seizures. Zinc pretreatment resulted in partially suppression of neurogenesis in the dentate gyrus of hippocampus, and protected mice from seizure-induced cognitive decline. Additionally, extracellular zinc was uptaken by microglia through zinc transporters and induced morphological changes characterized by activated microglia. These results suggest that zinc may be a important factor associated with epileptogenesis.
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