| Project/Area Number |
22791352
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脳腫瘍 / 免疫治療 / 樹状細胞 / 養子免疫療法 / インターフェロン / 長期免疫 |
|---|
| Research Abstract |
To make a contribution to clinical field, we examined the efficacy of immunotherapy for mouse brain tumor model with adoptive transfer and intratumoral delivery of dendritic cells in this study. First, mice with brain tumor received intratumoral injection of dendritic cells, and then received tumor antigen specific CD8 T cells intravenously. As a result, this combination of the treatment enhanced the homing of adoptive transferred T cells to the brain tumor site, and prolonged the survival time of the treated mice. The reason of this effective treatment was that intratumoral delivered dendritic cells made antigen presentation and induced chemokine production from tumor cells.
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