Next generation sequencing of susceptibility loci for intracranial aneurysms to identify disease-causal mutations

• Project/Area Number: 22791359
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: AKAGAWA Hiroyuki 東京女子医科大学, 医学部, テニュアトラック准教授 (60398807)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脳動脈瘤 / 遺伝子 / rare variant

Research Abstract

A susceptibility locus for intracranial aneurysms on chromosome14q23 was extensively analyzed with next generation sequencing. Positive linkage signal was successfully replicated in 14q22.3-14q24.3.

Research Products

• [Journal Article] Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort (2010)
  • Author(s): Krischek B, Tajima A, Akagawa H, Narita A, Ruigrok Y, Rinkel G, Wijmenga C, Feigl GC, Kim CJ, Hori T, Tatagiba M, Kasuya H, Inoue I
  • Journal Title: Neuroscience Volume: 169(1) Pages: 339-43
  • Peer Reviewed
• [Presentation] Confirmation of an association of TNFRSF13B sequence variants with intracranial aneurysms in Japanese patients (2011)
  • Author(s): Hiroyuki Akagawa, Taku Yoneyama, Hideaki Onda, Boris Krischek, Tsutomu Nishizawa, Hidetoshi Kasuya
  • Organizer: 2011 AANS 79th Annual Scientific Meeting
  • Place of Presentation: Colorado Convention Center, Denver, Colorado
• [Presentation] Confirmation of an association of TNFRSF13B sequence variants with intracranial aneurysms in Japanese patients (2011)
  • Author(s): Hiroyuki Akagawa
  • Organizer: 2011 American Association of Neurological Surgeons (AANS) 79^<th> Annual Meeting
  • Place of Presentation: Colorado Convention Center, Denver, Colorado
• [Presentation] 脳動脈瘤候補遺伝子のRare Variantを用いた関連解析 (2010)
  • Author(s): 赤川浩之、米山琢、恩田英明、西澤勉、岡田芳和、糟谷英俊
  • Organizer: 第11回日本分子脳神経外科学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-08-27
• [Presentation] 脳動脈瘤候補遺伝子のrare variantを用いた関連解析 (2010)
  • Author(s): 赤川浩之
  • Organizer: 第11回日本分子脳神経外科学会
  • Place of Presentation: 艮陵会館記念ホール(仙台市)
  • Year and Date: 2010-08-27