| Project/Area Number |
22791360
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
IKEDA Naokado 大阪医科大学, 医学部, 非常勤講師 (50434775)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 悪性脳腫瘍 / 神経膠芽腫 / 転移性脳腫瘍 / CPOX / 5-アミノレブリン酸 / プロトポルフィリンIX / 光線力学的診断 / 光線力学的治療 / 5aminolevulinic acid / malignant glioma / metastatic brain tumor / photodynamic diagnosis / coproporphyrinogen oxidase (CPOX) / glioma stem cell / ABCG2 transporter / 5ALA / 悪性神経膠腫 / 神経膠腫幹細胞 |
|---|
| Research Abstract |
Little is known, however, about the detailed molecular mechanisms underlying 5-ALA-induced fluorescence.
We analyzed transcriptome profiles for the genes encoding enzymes, transporters, and a transcription factor involved in the porphyrin-biosynthesis pathway for surgical removed malignant brain tumors.
The high mRNA level of CPOX expression was significantly well correlated with the phenotype of strong 5-ALA induced fluorescence. These findings were further confirmed by immunohistochemical studies with a CPOX-specific antibody. It is concluded that induction of CPOX gene expression is one of the key molecular mechanisms underlying the 5-ALA-induced fluorescence of malignant brain tumors.
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