Research that related to usefulness of evaluation using 18F-BPA-PET after treatment for malignant brain tumor

• Project/Area Number: 22791361
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka Medical College
• Principal Investigator: MATSUSHITA Yoko 大阪医科大学, 医学部, 助教 (70512094)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 脳腫瘍学 / 脳腫瘍 / PET / 化学療法 / 放射線治療 / 治療効果 / BPA / 画像診断 / LAT-1

Research Abstract

Investigating correlation with the result of^<18> F-BPA-PET scans and a prognosis, and pathologic examination were performed to the newly diagnosed cases of malignant glioma and the existing cases. It was shown that the diagnosis of tumor malignancy was possible by the lesion/normal brain ratio. The cutoff values for distinguishing tumor recurrence and radiation necrosis were defined. Repeat PET imaging was found to be useful for evaluating changes in glioma activity with respect to the treatment received.

Research Products

• [Journal Article] Phase II clinical study of boron neutron capture therapy combined with X-ray radiotherapy/temozolomide in patients with newly diagnosed glioblastoma multiforme-Study design and current status report (2011)
  • Author(s): Kawabata S, Takekita Y, ほか
  • Journal Title: Appl Radiat Isot Volume: 69 Pages: 1796-1799
  • Peer Reviewed
• [Journal Article] 硼素中性子捕捉療法について (2011)
  • Author(s): 川端信司、松下葉子, ほか
  • Journal Title: PET journal Volume: 15 Pages: 9-12
  • NAID: 40019066024
• [Presentation] ^<18> F-BPA-PETを用いたグリオーマの悪性度診断 (2012)
  • Author(s): 松下葉子, ほか
  • Organizer: 第35回日本脳神経CI学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-03-03
• [Presentation] ^<18>F-BPA-PETを用いたグリオーマの悪性度診断 (2012)
  • Author(s): 松下葉子, ほか
  • Organizer: 第35回日本脳神経CI学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-03-03
• [Presentation] 悪性脳腫瘍治療後における^<18> F-BPA-PETを用いた病態解析の有用性 (2011)
  • Author(s): 松下葉子, ほか
  • Organizer: 第29回日本脳腫瘍学会
  • Place of Presentation: 下呂
  • Year and Date: 2011-11-27
• [Presentation] 悪性脳腫瘍治療後における^<18>F-BPA-PETを用いた病態解析の有用性 (2011)
  • Author(s): 松下葉子, ほか
  • Organizer: 第29回日本脳腫瘍学会学術集会
  • Place of Presentation: 下呂
  • Year and Date: 2011-11-27
• [Presentation] F-BPA-PETを用いた再発悪性脳腫瘍の確実な診断 (2011)
  • Author(s): 松下葉子, ほか
  • Organizer: 日本脳神経外科学会第70回学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-10-14
• [Presentation] BPA-PETによる腫瘍内ホウ素集積の解析-BNCT照射計画における最適化の手法について (2011)
  • Author(s): 松下葉子, ほか
  • Organizer: 第8回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 徳島
  • Year and Date: 2011-09-17
• [Presentation] BPA-PETによる腫瘍内ホウ素集積の解析-BNCT照射計画における最適化の手法について- (2011)
  • Author(s): 松下葉子, ほか
  • Organizer: 第8回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 徳島
  • Year and Date: 2011-09-17
• [Presentation] Clinical results of glioblastoma treated with temozolomide in elderly patients (2011)
  • Author(s): Yoko Takekita, ほか
  • Organizer: The 4^<th> international neurosurgical winter Congress
  • Place of Presentation: 北海道,ルスツ
• [Presentation] Clinical results of glioblastoma treated with temozolomide in elderly patients (2011)
  • Author(s): Yoko Takekita, ほか
  • Organizer: The 4^<th> international neurosurgical winter congress
  • Place of Presentation: 北海道、ルスツ
• [Presentation] Amino acid PET(^<18>F-laveled borono-phenylalanine positron emission tomography) around our modified boron neutron capture therapy (2011)
  • Author(s): Shinji Kawabata, Yoko Takekita, ほか
  • Organizer: The 4^<th> international neurosurgical winter congress
  • Place of Presentation: 北海道、ルスツ
• [Presentation] 悪性神経膠腫患者の維持化学療法に伴う諸問題 (2010)
  • Author(s): 嶽北葉子, ほか
  • Organizer: 第28回日本脳腫瘍学会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-28
• [Presentation] 悪性神経膠腫患者の維持化学療法に伴う諸問題 (2010)
  • Author(s): 嶽北葉子, ほか
  • Organizer: 第28回 日本脳腫瘍学会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-28
• [Presentation] テモゾロミド併用放射線治療を行った高齢者膠芽腫症例の解析 (2010)
  • Author(s): 嶽北葉子, ほか
  • Organizer: 日本脳神経外科学会第69回学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-28
• [Presentation] テモゾロミド併用放射線治療を行った高齢者膠芽腫症例の解析 (2010)
  • Author(s): 嶽北葉子, ほか
  • Organizer: 日本脳神経外科学会 第69回学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-28
• [Presentation] 免疫組織化学を用いた25症例脳腫瘍患者に対するLAT1(L-type amino acidtransporter 1)発現について (2010)
  • Author(s): 平松亮、嶽北葉子, ほか
  • Organizer: 日本脳神経外科学会 第69回学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-28
• [Presentation] 当院における高齢者膠芽腫症例に対する治療成績の検討 (2010)
  • Author(s): 嶽北葉子, ほか
  • Organizer: 第15回日本脳腫瘍の外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-10-01
• [Presentation] 当院における高齢者膠芽腫症例に対する治療成績の検討 (2010)
  • Author(s): 嶽北葉子, ほか
  • Organizer: 第15回 日本脳腫瘍の外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-10-01
• [Presentation] Clinical results of Temozolomide for the elderly glioblastoma patients (2010)
  • Author(s): Yoko Takekita, ほか
  • Organizer: The 9^<th> International Conference of the Asian Clinical Oncology Society
  • Place of Presentation: 岐阜
  • Year and Date: 2010-08-26
• [Presentation] Clinical results of Temozolomide for the elderly glioblastoma patients (2010)
  • Author(s): Yoko Takekita, ほか
  • Organizer: The 7^<th> Asian Society for Neuro-Oncology
  • Place of Presentation: 韓国、ソウル
• [Presentation] ^<18>F-labeled BPA Positron Emission Tomography based Boron Neutron Capture Therapy-our New indications and possibility for any other brain malignancies (2010)
  • Author(s): Shinji Kawabata, Yoko Takekita, ほか
  • Organizer: The 7^<th> Asian Society for Neuro-Oncology
  • Place of Presentation: 韓国、ソウル
• [Book] Croatia Advances in the Biology, Imaging and Therapies for Glioblastoma (2011)
  • Author(s): S. Kawabata, Y. Matsushita, ほか
  • Total Pages: 424
  • Publisher: InTech
• [Book] Advances in the Biology, Imaging and Therapies for Glioblastoma (2011)
  • Author(s): S.Kawabata, Y.Matsushita, ほか
  • Publisher: InTech, Croatia