Functional analysis of STAT1 to elucidate molecular mechanisms regulating skeletal development by FGF
| Project/Area Number |
22791363
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨・軟骨代謝学 / 骨格形成 / 骨形成 / FGF / STAT1 / Fgf / Cfr / ERK / 顎形成 / Fgf18 / ゴルジ体 |
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| Research Abstract |
FGF, which is a family of proteins secreted from cells to convey cellular information, plays a indispensable role in skeletal development. Cells that received FGF transmit its information into the cells mainly through two proteins, ERK and STAT1. Crossing of mice genetically lacking either FGF or STAT1 demonstrated a possibility that STAT1 is important for formation of the skeletons of the lower jaw. In addition, I revealed that intracellular distribution of a protein, Cfr, is important for signal transduction by FGF.
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Report
(3 results)
Research Products
(2 results)
