Establishment of the treatment and pathophysiology based on the susceptibility gene in lumbar disc disease.
Project/Area Number |
22791365
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
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Research Institution | University of Toyama |
Principal Investigator |
SEKI Shoji 富山大学, 大学院・医学薬学研究部(医学), 助教 (00432112)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | CILP / 腰椎椎間板 / トランスジェニックマウス / 腰椎椎間板変性 / 椎間板変性モデル / MRI |
Research Abstract |
Safranin O staining in intervertebral disc were significantly decreased in Nucleus pulposus tissues of Tg mice compared to controls. MRI analysis indicated obvious progression of degenerative intervertebral discs in Tg mice, which suggested reduction of the intensity of lumbar T2 weighted MR imaging. The cervical intervertebral disc degeneration and hernia models were established by introducing instability into cervical vertebrate of CILP Tg mice. The histological analysis suggested that progression of intervertebral disc degeneration and regulation of TGF-βsignaling. There may be a possibility that CILP enhance intervertebral disc degeneration.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells.2010
Author(s)
Hori T, Kondo T, Kanamori M, Tabuchi Y, Ogawa R, Zhao QL, Ahmed K, Yasuda T, Seki S, Suzuki K, Kimura T.
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Journal Title
Cancer Lett.
Volume: 287
Pages: 98-108
Related Report
Peer Reviewed
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[Journal Article] Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells.2010
Author(s)
Hori T, Kondo T, Kanamori M, Tabuchi Y, Ogawa R, Zhao QL, Ahmed K, Yasuda T, Seki S, Suzuki K, Kimura T.
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Journal Title
J Orthop Res.
Volume: 28
Pages: 739-45
Related Report
Peer Reviewed
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[Presentation] CILP, cartilage intermediate layer protein, promotes lumbar disc degeneration.2010
Author(s)
hoji Seki, Noriyuki Tsumaki, Yoshiharu Kawaguchi, * Yumiko Abe, Kayo Suzuki, Akiko Iwai, Takeshi Oya, Shiro Ikegawa, and Tomoatsu Kimura
Organizer
ORS
Place of Presentation
ニューオーリンズ(アメリカ)
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