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Establishment of the treatment and pathophysiology based on the susceptibility gene in lumbar disc disease.

Research Project

Project/Area Number 22791365
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionUniversity of Toyama

Principal Investigator

SEKI Shoji  富山大学, 大学院・医学薬学研究部(医学), 助教 (00432112)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsCILP / 腰椎椎間板 / トランスジェニックマウス / 腰椎椎間板変性 / 椎間板変性モデル / MRI
Research Abstract

Safranin O staining in intervertebral disc were significantly decreased in Nucleus pulposus tissues of Tg mice compared to controls. MRI analysis indicated obvious progression of degenerative intervertebral discs in Tg mice, which suggested reduction of the intensity of lumbar T2 weighted MR imaging. The cervical intervertebral disc degeneration and hernia models were established by introducing instability into cervical vertebrate of CILP Tg mice. The histological analysis suggested that progression of intervertebral disc degeneration and regulation of TGF-βsignaling. There may be a possibility that CILP enhance intervertebral disc degeneration.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (53 results)

All 2012 2011 2010 Other

All Journal Article (18 results) (of which Peer Reviewed: 13 results) Presentation (35 results)

  • [Journal Article] Cartilage Intermediate Layer Protein (CILP) Regulation in Intervertebral Discs: The Effect of Age2012

    • Author(s)
      Wang Z, Kim JH, Higashino K, Kim SS, Wang S, Seki S, Hutton WC, Yoon ST.
    • Journal Title

      Degeneration, and BMP-2. Spine

      Volume: 37巻 Issue: 4 Pages: E203-E208

    • DOI

      10.1097/brs.0b013e31822dcf47

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of human amniotic mesenchymal stem cells and their chondrogenic differentiation2012

    • Author(s)
      Nogami M., Tsuno H., Koike C., Okabe M.,Yoshida T., Seki S., Matsui Y., Kimura T.,Nikaido T
    • Journal Title

      Transplantation

      Volume: 93(12) Issue: 12 Pages: 1221-8

    • DOI

      10.1097/tp.0b013e3182529b76

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adamts5 遺伝子と椎間板変性2012

    • Author(s)
      関 庄二、淺沼由美子、舛田浩一、川口善治、淺沼邦洋、木村友厚
    • Journal Title

      整形・災害外科

      Volume: 55巻 Pages: 118-119

    • Related Report
      2012 Final Research Report
  • [Journal Article] Adamts5 遺伝子と椎間板変性2012

    • Author(s)
      関 庄二
    • Journal Title

      整形・災害外科

      Volume: 55 Pages: 118-119

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cartilage Intermediate Layer Protein (CILP) Regulation in Intervertebral Discs : The Effect of Age, Degeneration, and BMP-22011

    • Author(s)
      Wang Z, Kim JH, Higashino K, Kim SS, Wang S, Seki S, Hutton WC, Yoon ST
    • Journal Title

      Spine J

      Volume: 37

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of ossification of the posterior longitudinal ligament by three-dimensional computed tomography and magnetic resonance imaging2011

    • Author(s)
      Kawaguchi Y, Urushisaki A, Seki S, Hori T, Asanuma Y, Kimura T
    • Journal Title

      Spine J

      Volume: 11 Pages: 927-32

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multi-focal Myxopapillary Ependymoma in the Lumbar and Sacral Regions Requiring Cranio-spinal Radiation Therapy : A Case Report2011

    • Author(s)
      Andoh H, Kawaguchi Y, Seki S, Asanuma Y, Fukuoka J, Ishizawa S, Kimura T
    • Journal Title

      Asian spine J

      Volume: 5 Pages: 68-72

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Os odontoideum with cervical mylopathy due to posterior subluxation of C1 presenting sleep apnea2011

    • Author(s)
      Kawaguchi Y, Iida M, Seki S, Nakano M, Yasuda T, Asanuma Y, Kimura T
    • Journal Title

      J Orthop Sci

      Volume: 16 Pages: 329-33

    • NAID

      10029573610

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative meningitis in patients with cervical cord tumor : a case report2011

    • Author(s)
      Kawaguchi Y, Seki S, Yasuda T, Nakamura Y, Nakano M, Kimura T
    • Journal Title

      Asian Spine J

      Volume: 4 Pages: 136-40

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 原発性無月経を伴った、特発性頚椎後弯症の1例2011

    • Author(s)
      峯隼人、関庄二、川口善治、中野正人、木村友厚
    • Journal Title

      雑誌整形

      Volume: 62 Pages: 1073-1076

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells.2010

    • Author(s)
      Hori T, Kondo T, Kanamori M, Tabuchi Y, Ogawa R, Zhao QL, Ahmed K, Yasuda T, Seki S, Suzuki K, Kimura T.
    • Journal Title

      Cancer Lett.

      Volume: 287 Pages: 98-108

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells.2010

    • Author(s)
      Hori T, Kondo T, Kanamori M, Tabuchi Y, Ogawa R, Zhao QL, Ahmed K, Yasuda T, Seki S, Suzuki K, Kimura T.
    • Journal Title

      J Orthop Res.

      Volume: 28 Pages: 739-45

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 頸椎椎弓形成術後患者の職業復帰からみたADL2010

    • Author(s)
      川口善治, 安田剛敏, 関庄二, 野上重治, 金森昌彦, 木村友厚
    • Journal Title

      中部整災誌

      Volume: 53 Pages: 45-46

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 脊椎靱帯骨化症患者における全脊椎骨化巣の評価と脊椎の骨化領域2010

    • Author(s)
      川口善治, 関庄二, 浅沼由美子, 木村友厚
    • Journal Title

      中部整災誌

      Volume: 52 Pages: 1253-54

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 腰椎後方固定術の移植骨には腰椎局所骨または腸骨どちらが有用であるか?2010

    • Author(s)
      関庄二, 川口善治, 淺沼由美子, 安田剛敏, 箭原康人, 木村友厚
    • Journal Title

      中部整災誌

      Volume: 53 Pages: 585-586

    • NAID

      10029798326

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 頸椎伸展位MRIが有用であった頸髄症の1例2010

    • Author(s)
      淺沼由美子, 川口善治, 関庄二, 木村友厚, 笠井裕一
    • Journal Title

      中部整災誌

      Volume: 53 Pages: 217-218

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 椎弓形成術後後彎変形により症状増悪をきたした頸椎後縦靱帯骨化症の1例2010

    • Author(s)
      仲岡英幸, 関庄二, 川口善治, 浅沼由美子, 鈴木賀代, 木村友厚
    • Journal Title

      整形外科

      Volume: 61 Pages: 326-329

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【インプラント感染 その予防と対策】脊椎インプラント感染早期深部感染の危険因子2010

    • Author(s)
      川口善治, 安田剛敏, 関庄二, 木村友厚
    • Journal Title

      整形・災害外科

      Volume: 53 Pages: 625-629

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effect of a selective c-Fos/AP-1 inhibitor on the human nucleus pulposus cells.2012

    • Author(s)
      Yasuhito Yahara, Shoji Seki, Hiraku Motomura, Yoshito Matsui, Mami Higashimoto, Syunichi Shiozawa, Tomoatsu Kimura.
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2012-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] c-Fos/AP-1阻害薬(T-5224)の軟骨および椎間板変性抑制効果2012

    • Author(s)
      関 庄二、元村 拓、塩沢俊一、木村友厚
    • Organizer
      応用薬理シンポジ ウム
    • Place of Presentation
      ベルクラシック甲府(山梨県)
    • Year and Date
      2012-09-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Mechanical stress loading of cervical intervertebral disc in CILP transgenic mice promotes intervertebral disc degeneration.2012

    • Author(s)
      Shoji Seki, Noriyuki Tsumaki, Hiraku Motomura, Yoshiharu Kawaguchi, Yoshito Matsui, Kayo Suzuki, Tomoatsu Kimura.
    • Organizer
      ISSLS
    • Place of Presentation
      アムステルダム(オランダ)
    • Related Report
      2012 Final Research Report
  • [Presentation] Mechanical stress loading of cervical intervertebral disc in CILP transgenic mice promotes intervertebral disc degeneration.2012

    • Author(s)
      関 庄二
    • Organizer
      ISSLS
    • Place of Presentation
      アムステルダム(オランダ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 術後1年でcoronal balanceの悪化および腰痛が再燃した成人側弯症の1例2011

    • Author(s)
      関庄二, 川口善治, 中野正人, 安田剛敏, 堀岳史, 箭原康人, 牧野紘士, 木村友厚
    • Organizer
      第22回北陸脊椎脊髄外科研究会
    • Place of Presentation
      富山
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗凝固療法中に発症した腸腰筋血腫により大腿神経麻庫をきたした2症例2011

    • Author(s)
      浦田隆司、関庄二、川口善治、中野正人、安田剛敏、堀岳史、木村友厚
    • Organizer
      北陸集談会
    • Place of Presentation
      富山
    • Year and Date
      2011-10-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lenke type 1A curve の特徴に基づくLIVの決定法について2011

    • Author(s)
      関庄二, Bartley C., Petcharaporn M., Bastrom T., Yaszay B., Newton P., Harms Study Group
    • Organizer
      第45回日本側彎症学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] 治療に難渋したパーキンソン病を伴う骨粗鬆症性椎体圧潰の1例2010

    • Author(s)
      中野正人, 川口善治, 安田剛敏, 関庄二, 堀岳史, 峯隼人, 田中修平, 木村友厚
    • Organizer
      第21回北陸脊椎脊髄外科研究会
    • Place of Presentation
      福井
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 上位腰椎椎間板ヘルニアの臨床像と治療成績2010

    • Author(s)
      安田剛敏, 川口善治, 中野正人, 関庄二, 堀岳史, 八野田純, 金森昌彦, 木村友厚
    • Organizer
      第21回北陸脊椎脊髄外科研究会
    • Place of Presentation
      福井
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 頚胸移行部に発生した硬膜外血管腫の1例2010

    • Author(s)
      八野田純, 堀岳史, 安田剛敏, 川口善治, 中野正人, 関庄二, 金森昌彦, 木村友厚
    • Organizer
      第21回北陸脊椎脊髄外科研究会
    • Place of Presentation
      福井
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 原発性無月経を伴った特発性頚椎後弯症の1例2010

    • Author(s)
      峯隼人, 関庄二, 川口善治, 中野正人, 木村友厚, 海木玄郷
    • Organizer
      第186回北陸整形外科集談会
    • Place of Presentation
      福井
    • Year and Date
      2010-09-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] ADAMTS5遺伝子 ノックダウンにおける椎間板変性抑制効果2010

    • Author(s)
      関 庄二, 阿部由美子,川口善治,浅沼邦洋, 舛田浩一,木村友厚
    • Organizer
      第83回日本整形外科学術集会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Final Research Report
  • [Presentation] CILP, cartilage intermediate layer protein, promotes lumbar disc degeneration.2010

    • Author(s)
      hoji Seki, Noriyuki Tsumaki, Yoshiharu Kawaguchi, * Yumiko Abe, Kayo Suzuki, Akiko Iwai, Takeshi Oya, Shiro Ikegawa, and Tomoatsu Kimura
    • Organizer
      ORS
    • Place of Presentation
      ニューオーリンズ(アメリカ)
    • Related Report
      2012 Final Research Report
  • [Presentation] The relationship between the finding of calcification of aorta and both the grade of lumbar spondylosis and bone mineral density.2010

    • Author(s)
      Kawaguchi Y., Nobukiyo M., Nakano M., Seki S., Sainoh H., Kimura T.
    • Organizer
      ISSLS Annual Meeting
    • Place of Presentation
      Auckland, New zealand.
    • Related Report
      2010 Annual Research Report
  • [Presentation] Evaluation of ossified lesions in the whole spine and surgical results in patients with ossification of the posterior longitudinal ligament.2010

    • Author(s)
      Kawaguchi Y., Nkano M., Yasuda T., Seki S., Kimura T.
    • Organizer
      ISSLS Annual Meeting
    • Place of Presentation
      Auckland, New zealand.
    • Related Report
      2010 Annual Research Report
  • [Presentation] Percutaneous vertebroplasty with calcium phosphate cement for osteoporotic vertebral fractures : analysis of the poor clinical outcome.2010

    • Author(s)
      Nakano M., Kawaguchi Y., Yasuda T., Seki S., Kimura T.
    • Organizer
      37th Annual Meeting International Society for the Study of the Lumbar Spine
    • Place of Presentation
      Auckland, New zealand.
    • Related Report
      2010 Annual Research Report
  • [Presentation] Long-term follow-up study of vertebroplasty with calcium phosphate cemerit for osteoporotic vertebral fractures2010

    • Author(s)
      Nakano M., Kawaguchi Y., Yasuda T., Seki S., Kimura T., Hirano N.
    • Organizer
      37th Annual Meeting International Society for the Study of the Lumbar Spine
    • Place of Presentation
      Auckland, New zealand
    • Related Report
      2010 Annual Research Report
  • [Presentation] Small interference RNA(siRNA) of ADAMTS4 and ADAMTS5 in nucleus pulposus cells in vitro and effects of ADAMTS5 siRNA in the rabbit a nular needle puncture model.2010

    • Author(s)
      Seki S., et, al, al.
    • Organizer
      37th Annual Meeting International Society for the Study of the Lumbar Spine
    • Place of Presentation
      Auckland, Newzeland
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pathomechanism of myelopathy and surgical results of laminoplasty in elderly patients with cervical spondylosis.2010

    • Author(s)
      Kawaguchi Y., Nakano M., Yasuda T., Seki S., Kimura T.
    • Organizer
      1st Annual Meeting of Cervical Spine Research Society Asia Pacific Section
    • Place of Presentation
      Kobe
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脊椎手術における術野感染の実態と治療2010

    • Author(s)
      川口善治, 安田剛敏, 中野正人, 関庄二, 木村友厚
    • Organizer
      第114回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] 頚椎前後屈MRIが診断の決め手となった5症例2010

    • Author(s)
      関庄二, 淺沼由美子, 川口善治, 安田剛敏, 木村友厚
    • Organizer
      第114回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高齢者頚椎症性脊髄症の発症メカニズムと頚椎椎弓形成術の術後成績2010

    • Author(s)
      川口善治, 中野正人, 安田剛敏, 関庄二, 金森昌彦, 木村友厚
    • Organizer
      第39回日本脊椎脊髄病学会
    • Place of Presentation
      高知
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨粗鬆症性椎体骨折に対するリン酸カルシウム骨ペーストを用いた椎体形成術の中長期成績-術後5年以上2010

    • Author(s)
      中野正人, 川口善治, 安田剛敏, 関庄二, 木村友厚, 平野典和
    • Organizer
      第39回日本脊椎脊髄病学会
    • Place of Presentation
      高知
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨粗鬆症性椎体骨折に対するリン酸カルシウム骨カルシウム骨ペーストを用いた椎体形成術の有用性と問題点:成績不良例の原因分析と対策について2010

    • Author(s)
      中野正人, 川口善治, 安田剛敏, 関庄二, 木村友厚, 平野典和
    • Organizer
      第39回日本脊椎脊髄病学会
    • Place of Presentation
      高知
    • Related Report
      2010 Annual Research Report
  • [Presentation] 椎体偽関節後の遅発性神経麻痺に対する後方アプローチによる手術治療の成績と問題点2010

    • Author(s)
      安田剛敏, 中野正人, 川口善治, 関庄二, 渡邉健太, 八野田純, 金森昌一彦, 木村友厚
    • Organizer
      第39回日本脊椎脊髄病学会
    • Place of Presentation
      高知
    • Related Report
      2010 Annual Research Report
  • [Presentation] 頚髄症における頚椎前後屈MRIの有用性-水平断像の解析について-2010

    • Author(s)
      関庄二, 他
    • Organizer
      第39回日本脊椎脊髄病学会
    • Place of Presentation
      高知
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脊椎靭帯骨化症患者における全脊椎骨下巣の評価と骨化領域に関わる全身因子2010

    • Author(s)
      川口善治, 中野正人, 安田剛敏, 関庄二, 木村友厚
    • Organizer
      第83回日本整形外科学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腰椎手術患者における精神的背景の分析2010

    • Author(s)
      金森昌彦, 安田剛敏, 川口善治, 関庄二, 阿部由美子, 鈴木賀代, 木村一友厚, 筒井未春
    • Organizer
      第83回日本整形外科学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脊椎腫瘍手術の術後感染に対する予防と治療2010

    • Author(s)
      安田剛敏, 金森昌彦, 川口善治, 関庄二, 堀岳史, 鈴木賀代, 舟田久, 木村友厚
    • Organizer
      第43回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脊椎手術における術野感染の予防対策2010

    • Author(s)
      川口善治, 安田剛敏, 中野正人, 関庄二, 峯隼人, 木村友厚
    • Organizer
      第115回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] CILP(cartilage intermediate layer protein)トランスジェニックマウスの椎間板変性促進効果2010

    • Author(s)
      関庄二, 他
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] EWS-CHOP type1融合蛋白質はosteopontin遺伝子の発現を抑制する2010

    • Author(s)
      鈴木賀代, 松井好人, 関庄二, 久保貴博, 安井夏生, 木村友厚
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] 原発性無月経を伴った, 特発性頚椎後弯症の一例2010

    • Author(s)
      関庄二, 川口善治, 中野正人, 峯隼人, 木村友厚
    • Organizer
      第44回日本側彎症学会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト髄核細胞を用いた選択的c-Fos AP-1 阻害薬の椎間板代謝に及ぼす効果

    • Author(s)
      箭原 康人
    • Organizer
      第27回日本整形外科学会基礎
    • Place of Presentation
      名古屋国際会議場 (愛知)
    • Related Report
      2012 Annual Research Report
  • [Presentation] c-Fos/AP-1阻害薬(T-5224)の軟骨および椎間板変性抑制効果

    • Author(s)
      関 庄二
    • Organizer
      応用薬理シンポジウム
    • Place of Presentation
      ベルクラシック甲府(山梨)
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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