| Project/Area Number |
22791367
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
OHBA Tetsuro 山梨大学, 医学部・附属病院, 助教 (70456490)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
|---|
| Keywords | TSLP / TGF-b / 椎間板 / マウス / 低酸素状況 |
|---|
| Research Abstract |
Increased TSLP and phosphorylated NF-kB expressions were observed in HD tissue samples associated with reduced expression of phosphorylated Smad2/3(an indicator of active TGF-βsignaling) and vice versa in posterior lumbar spinal fusion samples. The pharmacological blockade of endogenous TGF-βactivity induced TSLP, but not MCP-1, IL-6 and MMP-3, expression. Endogenous TGF-b activity limits TSLP expression in intervertebral disc tissue in the steady states via suppression of NF-kB. In occurring phase of HD, TSLP production might be induced via NF-kB activation due to lack of endogenous TGF-βactivity by unidentified mechanisms, thereby eventually contributing to natural resorption of HD.
|
