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A potential role of thymic stromal lymphopoietin in the disc degeneration.

Research Project

Project/Area Number 22791367
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionUniversity of Yamanashi

Principal Investigator

OHBA Tetsuro  山梨大学, 医学部・附属病院, 助教 (70456490)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
KeywordsTSLP / TGF-b / 椎間板 / マウス / 低酸素状況
Research Abstract

Increased TSLP and phosphorylated NF-kB expressions were observed in HD tissue samples associated with reduced expression of phosphorylated Smad2/3(an indicator of active TGF-βsignaling) and vice versa in posterior lumbar spinal fusion samples. The pharmacological blockade of endogenous TGF-βactivity induced TSLP, but not MCP-1, IL-6 and MMP-3, expression. Endogenous TGF-b activity limits TSLP expression in intervertebral disc tissue in the steady states via suppression of NF-kB. In occurring phase of HD, TSLP production might be induced via NF-kB activation due to lack of endogenous TGF-βactivity by unidentified mechanisms, thereby eventually contributing to natural resorption of HD.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All Other

All Journal Article (1 results) Remarks (2 results)

  • [Journal Article] Endogenous TGF-b activity limits TSLP expression in intervertebral dis ctissue via suppression of NF-kB

    • Author(s)
      Yong Zhu, Tetsuro Ohba.
    • Journal Title

      Arthritis & Rheumatism

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.yamanashi.ac.jp/clinical/orthop/research.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.yamanashi.ac.jp/clinical/orthop/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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