ER Stress response in osteoclastogenesis

Research Project

Project/Area Number	22791368
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthopaedic surgery
Research Institution	University of Yamanashi
Principal Investigator	KOYAMA Kensuke 山梨大学, 医学部・附属病院, 助教 (80456491)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	破骨細胞 / 小胞体ストレス
Research Abstract	SubAB reduced arthritis score and synovitis in collagen induced arthritis(CIA) model mice. We used chronic model but the suppressive effects of SubAB was similar to acute model. We investigate osteoclasts in this model. TRAP positive osteoclasts in SubAB were less than control in pathological analysis. Next, we investigated the effects of SubAB to osteoclastogenesis in vitro. SubAB inhibited osteoclastogenesis directly in RAW264. 7 cell and mouse bone marrow cell. This concentration of SubAB did not affect differentiation of macrophage in mouse bone marrow cell.