| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
It is well known that bone remodeling depends on a delicate balance between formation and resorption of bone tissues, and osteoblasts and bone-resorbing osteoclasts play central roles in this bone remodeling. But the role of the blood coagulation system in bone remodeling is still unclear. In the present study, we evaluated the effect of APC on osteoblast proliferation and osteoclast differentiation. We found that APC stimulates osteoblast proliferation by activating p44/42 MAP kinase via EPCR and suppresses human osteoclast differentiation through inactivation of NF-κB via EPCR.
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