| Project/Area Number |
22791376
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMAMOTO Koji 京都大学, 医学研究科, 助教 (70536565)
|
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 変形性関節症 / メカニカルストレス / 遺伝子改変マウス / TRPV4 / Sox9 |
|---|
| Research Abstract |
In vivo observation of the Sox9 expression using Sox9-EGFP mice revealed that the Sox9 on the articular surface was increased temporally through TRPV4, which is one of the mechano-gated channels in chondrocytes, at the initial stage of osteoarthritis(OA). In addition, TRPV4 knock-out mice exhibited severer degradation of cartilage in the experimental OA model than wild-type mice. Furthermore, a selective agonist for TRPV4, GSK1016790A, induced the temporal expression of Sox9 in chondrocytes and was found to have a potential to inhibit the progression of OA.
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