| Project/Area Number |
22791380
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
MAENO Koichiro 神戸大学, 大学院・医学研究科, 助教 (70403269)
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| Research Collaborator |
NISHIDA Kotaro 神戸大学, 医学部附属病院, 講師 (00379372)
KAKUTANI Kenichiro 神戸大学, 医学部附属病院, 助教 (10533739)
YAMAMOTO Junya 神戸大学, 大学院・医学研究科, 大学院生
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脊椎脊髄病学 / 椎間板 / FasL / Fas / アポトーシス / シグナル伝達 / 炎症性サイトカイン |
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| Research Abstract |
The production of pro-inflammatory cytokines was found to be far larger at the co-culture group of macrophages and intervertebral nucleus pulposus cells with over-expression of Fas Ligand(FasL) which is transmembrane protein. Furthermore, it is found that the expression of ADAM(A Disintegrin And Metalloproteinase) 10, which controls the expression of FasL, also increases. FasL and ADAM10 play an important role in the production of pro-inflammatory cytokines coming from interaction of the intervertebral nucleus pulposus cells and macrophages.
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