|Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Mutations in MMP2 gene results in unique skeletal phenotype called osteolysis, which is characterized by multiple joint distraction and severe osteoporosis. The pathology of joint damages in osteolysis mimics rheumatoid synovitis, however, the underlining molecular mechanism how inactivated mutation in MMP2 results in osteolysis is largely unknown. In this study, we tried to develop an animal model for osteolysis. We have made a conditional transgenic mouse carring an mutated MMP2 gene, which can be over-expressed under specific condition. This mouse would be useful for understanding the roles of MMP2 during the development of osteolysis.