| Project/Area Number |
22791390
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 関節病学 / 特発性大腿骨頭壊死症 / ステロイド性大腿骨頭壊死症 / アルコール性大腿骨頭壊死症 / 動物モデル / 自然免疫機構 |
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| Research Abstract |
The aims of present study were to establish animal models of idiopathic osteonecrosis, and to clarify role of innate immune signaling in the development of idiopathic osteonecrosis of the femoral head. As a result, we could clarify these insights as follows :(1) weightbearing dose not contribute to the development of corticosteroid-induced osteonecrosis of the femoral head,(2) we could developed animal model of alcohol-induced osteonecrosis of the femoral head,(3) activation of innate immune signaling via toll-like receptor is require to develop corticosteroid-induced osteonecrosis of the femoral head,(4) relative differences in the activation of IRF7 and NF-kB lead to the development of osteonecrosis of the femoral head,(5) absence of any response to corticosteroid therapy in the liver may be implicated in the pathogenesis of osteonecrosis of the femoral head in clinically. These results will help us in the future to elucidate the pathogenesis of idiopathic osteonecrosis of the femoral head.
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