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Role of innate immune signaling in the development of idiopathic osteonecrosis of the femoral head

Research Project

Project/Area Number 22791390
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionSapporo Medical University

Principal Investigator

OKAZAKI Shunichiro  札幌医科大学, 医学部, 助教 (70404647)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords関節病学 / 特発性大腿骨頭壊死症 / ステロイド性大腿骨頭壊死症 / アルコール性大腿骨頭壊死症 / 動物モデル / 自然免疫機構
Research Abstract

The aims of present study were to establish animal models of idiopathic osteonecrosis, and to clarify role of innate immune signaling in the development of idiopathic osteonecrosis of the femoral head. As a result, we could clarify these insights as follows :(1) weightbearing dose not contribute to the development of corticosteroid-induced osteonecrosis of the femoral head,(2) we could developed animal model of alcohol-induced osteonecrosis of the femoral head,(3) activation of innate immune signaling via toll-like receptor is require to develop corticosteroid-induced osteonecrosis of the femoral head,(4) relative differences in the activation of IRF7 and NF-kB lead to the development of osteonecrosis of the femoral head,(5) absence of any response to corticosteroid therapy in the liver may be implicated in the pathogenesis of osteonecrosis of the femoral head in clinically. These results will help us in the future to elucidate the pathogenesis of idiopathic osteonecrosis of the femoral head.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2013 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (12 results)

  • [Journal Article] High risk of osteonecrosis of the femoral head in autoimmune disease patients showing no immediate increase in hepatic enzyme under steroid therapy2013

    • Author(s)
      S Okazaki, S Nagoya, M Yamamoto, K Tateda, H Takahashi, T Yamashita, H Matsumoto
    • Journal Title

      Rheumatology International

      Volume: (in press) Issue: 1 Pages: 51-55

    • DOI

      10.1007/s00296-011-2295-y

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ステロイド性大腿骨頭壊死症の発生要因の検討-肝臓機能と大腿骨頭壊死-2011

    • Author(s)
      岡崎俊一郎, ら
    • Journal Title

      東日本整形災害外科学会雑誌

      Volume: 23 Pages: 66-68

    • NAID

      10028163609

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] ステロイド性大腿骨頭壊死症の発生における荷重の影響2011

    • Author(s)
      岡崎俊一郎
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] アルコール性大腿骨頭壊死症動物モデル作製2011

    • Author(s)
      岡崎俊一郎
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ステロイド性大腿骨頭壊死症の発生における荷重の影響2011

    • Author(s)
      岡崎俊一郎
    • Organizer
      第47回日本股関節学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2011-10-07
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] アルコール性大腿骨頭壊死症動物モデル作製2011

    • Author(s)
      岡崎俊一郎
    • Organizer
      第47回日本股関節学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2011-10-07
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ステロイド性大腿骨頭壊死症発生における自然免疫シグナリングの役割2011

    • Author(s)
      岡崎俊一郎
    • Organizer
      第39回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] MyD88 independent pathway promotes development of alcohol-induced osteonecrosis of the femoral head2011

    • Author(s)
      OKAZAKI S
    • Organizer
      Research Society on Alcoholism meeting 2011
    • Place of Presentation
      アトランタ米国
    • Year and Date
      2011-06-27
    • Related Report
      2011 Final Research Report
  • [Presentation] MyD88 independent pathway promotes development of alcohol-induced osteonecrosis of the femoral head2011

    • Author(s)
      Shunichiro OKAZAKI
    • Organizer
      Research Society on Alcoholism meeting2011
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] アルコール性大腿骨頭壊死症と肝機能障害の関係2011

    • Author(s)
      岡崎俊一郎
    • Organizer
      第94回日本法医学会総会
    • Place of Presentation
      福島
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ステロイド性大腿骨頭壊死症の発生における荷重の影響2011

    • Author(s)
      岡崎俊一郎
    • Organizer
      第121回北海道整形災害外科学会
    • Place of Presentation
      旭川
    • Year and Date
      2011-06-12
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] アルコール性大腿骨頭壊死症動物モデル作製2011

    • Author(s)
      岡崎俊一郎
    • Organizer
      第121回北海道整形災害外科学会
    • Place of Presentation
      旭川
    • Year and Date
      2011-06-12
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ステロイド誘発大腿骨頭壊死症の発生要因の検討-肝臓機能と大腿骨頭壊死-2011

    • Author(s)
      岡崎俊一郎
    • Organizer
      第84回日本整形外科学会学術総会
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ステロイド性大腿骨頭壊死症の発生要因としての肝機能2010

    • Author(s)
      岡崎俊一郎
    • Organizer
      日本股関節学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-01
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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