The investigation of the bone metabolism in hypothalamus arcuate nucleus

Research Project

Project/Area Number	22791395
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthopaedic surgery
Research Institution	Jichi Medical University
Principal Investigator	SASANUMA Hideyuki 自治医科大学, 医学部, 研究員 (50528651)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	骨・軟骨代謝 / 中枢神経
Research Abstract	To investigate the bone metabolism of AgRP neurons in the hypothalamus arcuate nucleus, we focused PDK1 which was a important neurotransmitter in PI3K pathway. We generated AGRP neuron-specific PDK1 knockout(AGRPPdk1-/-) mice and analyzed the bone metabolism of AGRPPdk1-/-mice. These mice showed oeteopenia. This singaling by AgRP neuron might control the GHRH-GH-IGF1 axis in the skeleton.