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The investigation of the bone metabolism in hypothalamus arcuate nucleus

Research Project

Project/Area Number 22791395
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionJichi Medical University

Principal Investigator

SASANUMA Hideyuki  自治医科大学, 医学部, 研究員 (50528651)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords骨・軟骨代謝 / 中枢神経
Research Abstract

To investigate the bone metabolism of AgRP neurons in the hypothalamus arcuate nucleus, we focused PDK1 which was a important neurotransmitter in PI3K pathway. We generated AGRP neuron-specific PDK1 knockout(AGRPPdk1-/-) mice and analyzed the bone metabolism of AGRPPdk1-/-mice. These mice showed oeteopenia. This singaling by AgRP neuron might control the GHRH-GH-IGF1 axis in the skeleton.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] AgRPニューロンによる骨代謝2010

    • Author(s)
      笹沼秀幸
    • Journal Title

      日本整形外科学会雑誌

      Volume: 84

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] AgRPニューロンによる骨代謝2011

    • Author(s)
      笹沼秀幸
    • Organizer
      日本骨代謝学会
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] AgRPニューロンによる骨代謝2010

    • Author(s)
      笹沼秀幸
    • Organizer
      日本整形外科基礎学術集会
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

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Published: 2010-11-30   Modified: 2016-04-21  

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