Schwann Cell Plasticity after Spinal Cord Injury Shown by Neural Crest Lineage Cells
Project/Area Number |
22791398
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 脊髄損傷 / シュワン細胞 / 再生医療 / 脱分化 / 再分化 / 髄鞘化 / 神経堤細胞 |
Research Abstract |
After spinal cord injury(SCI), various cell types are recruited to the lesion site, including Schwann cells, which originate in the neural crest. Here, we investigated the differentiation states, migration patterns, and roles of neural crest derivatives following SCI, using a transgenic mouse line carrying neural crest-specific reporters, P0-Cre/Floxed-EGFP. This study draws on the advantages offered by transgenic mouse lines bearing a genetic cell-lineage marker and extends previous work by describing the origins and behavior of the neural crest-derived cells that contribute to endogenous repair after SCI. This process is a novel repair mechanism for the lesioned mammalian spinal cord.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice2011
Author(s)
Asada N, Takase M, Nakamura J, Oguchi A, Asada M, Suzuki N, Yamamura KI, Nagoshi N, Shibata S, Rao TN, Fehling HJ, Fukatsu A, Minegishi N, Kita T, Kimura T, Okano H, Yamamoto M, Yanagita M
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Journal Title
J Clin Invest
Volume: 121
Pages: 3981-90
NAID
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[Journal Article] Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero2011
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Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, Nakamura-Ishizu A, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T
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Journal Title
J Exp Med
Volume: 208
Pages: 949-60
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[Journal Article] Schwann-Spheres Derived from Injured Peripheral Nerves in Adult Mice-Their In Vitro Characterization and Therapeutic Potential2011
Author(s)
Takagi T, Ishii K, Shibata S, Yasuda A'^2, Sato M, Nagoshi N, Saito H, Okano HJ, Toyama Y, Okano H, Nakamura M
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[Journal Article] The dual origin of the peripheral olfactory system : placode and neural crest2011
Author(s)
Katoh H, Shibata S, Fukuda K, Sato M, Satoh E, Nagoshi N, Minematsu T, Matsuzaki Y, Akazawa C, Toyama Y, Nakamura M, Okano H
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Journal Title
Mol Brain
Volume: 4
Pages: 34-34
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[Journal Article] Sox10-Venus mice : a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes2010
Author(s)
Shibata S, Yasuda A, Renault-Mihara F, Suyama S, Katoh H, Inoue T, Inoue YU, Nagoshi N, Sato M, Nakamura M, Akazawa C, Okano H
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Journal Title
Mol Brain
Volume: 3
Pages: 31-31
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[Journal Article] Induction of neural crest cells from mouse embryonic stem cells in a serum-free monolayer culture2010
Author(s)
Aihara Y, Hayashi Y, Hirata M, Ariki N, Shibata S, Nagoshi N, Nakanishi M, Ohnuma K, Warashina M, Michiue T, Uchiyama H, Okano H, Asashima M, Furue MK
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Journal Title
Int J Dev Biol
Volume: 54
Pages: 1287-94
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[Journal Article] Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury2010
Author(s)
Tsuji O, Miura K, Okada Y, Fujiyoshi K, Mukaino M, Nagoshi N, Kitamura K, Kumagai G, Nishino M, Tomisato S, Higashi H, Nagai T, Katoh H, Kohda K, Matsuzaki Y, Yuzaki M, Ikeda E, Toyama Y, Nakamura M, Yamanaka S, Okano H
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Journal Title
Proc Natl Acad Sci USA
Volume: 107
Pages: 12704-9
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