| Project/Area Number |
22791401
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Clinical research Center, National Hospital Organization Murayama Medical Center (2011)
Keio University (2010) |
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Principal Investigator |
FUJIYOSHI Kanehiro 独立行政法人国立病院機構村山医療センター(臨床研究センター), 整形外科, 医員 (80365303)
|
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脊髄損傷 / MRI / コモンマーモセット / 髄鞘 / 脱髄 / 再髄鞘化 / 神経幹細胞移植 / q-spaceイメージング / 神経管細胞移植 |
|---|
| Research Abstract |
Here we developed the "Myelin map," an enhanced myelin visualization method based on q-space MR imaging. This method visualizes the highly restricted diffusion of water molecules in myelin sheaths. Myelin maps accurately depicted the poor myelination in myelin-deficient mice, the demyelination/remyelination in marmoset chemical SCI, and the remyelination after allogeneic NS/PC transplantation in marmosets. Myelin maps have an unparalleled ability to visualize demyelination/remyelination and the potential for immediate clinical application as a powerful tool for researchers and clinicians examining diseases of the central nervous system(CNS).
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