Elucidation of the mechanism of the spinal cord injury by q-space imaging
Project/Area Number |
22791401
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
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Research Institution | Clinical research Center, National Hospital Organization Murayama Medical Center (2011) Keio University (2010) |
Principal Investigator |
FUJIYOSHI Kanehiro 独立行政法人国立病院機構村山医療センター(臨床研究センター), 整形外科, 医員 (80365303)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 脊髄損傷 / MRI / コモンマーモセット / 髄鞘 / 脱髄 / 再髄鞘化 / 神経幹細胞移植 / q-spaceイメージング / 神経管細胞移植 |
Research Abstract |
Here we developed the "Myelin map," an enhanced myelin visualization method based on q-space MR imaging. This method visualizes the highly restricted diffusion of water molecules in myelin sheaths. Myelin maps accurately depicted the poor myelination in myelin-deficient mice, the demyelination/remyelination in marmoset chemical SCI, and the remyelination after allogeneic NS/PC transplantation in marmosets. Myelin maps have an unparalleled ability to visualize demyelination/remyelination and the potential for immediate clinical application as a powerful tool for researchers and clinicians examining diseases of the central nervous system(CNS).
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Clinical significance of diffusion tensor tractography as a predictor of functional recovery after laminoplasty in patients with cervical compressive myelopathy2012
Author(s)
Nakamura M, Fujiyoshi K, Tsuji O, Konomi T, Hosogane N, Watanabe K, Tsuji T, Ishii K, Momoshima S, Toyama Y, Chiba K, Matsumoto M
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Peer Reviewed
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[Journal Article] Human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury2011
Author(s)
Kitamura K, Fujiyoshi K, Yamane J, Toyota F, Hikishima K, Nomura T, Funakoshi H, Nakamura T, Aoki M, Toyama Y, Okano H, Nakamura M
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Related Report
Peer Reviewed
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[Journal Article] Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord2011
Author(s)
Yasuda A, Tsuji O, Shibata S, Nori S, Takano M, Kobayashi Y, Takahashi Y, Fujiyoshi K, Hara CM, Miyawaki A, Okano HJ, Toyama Y, Nakamura M, Okano H
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Journal Title
Stem Cells
Volume: 29(12)
Pages: 1983-94
Related Report
Peer Reviewed
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[Journal Article] Cervical intramedullary ependymoma masquerading as cervical spondylotic myelopathy on MRI analysis2011
Author(s)
Tsuji O, Nakamura M, Fujiyoshi K, Ishii K, Watanabe K, Hosogane N, Tsuji T, Momoshima S, Toyama Y, Chiba K, Matsumoto M
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice2011
Author(s)
Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Yamanaka S, Nakamura M, Okano H
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Journal Title
Proc Natl Acad Sci USA
Volume: 108(40)
Pages: 16825-30
Related Report
Peer Reviewed
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[Journal Article] Human hepatocyte growth factor promotes funct ional recovery in primates after spinal cord injury2011
Author(s)
Kitamura K, Fujiyoshi K, Yamane J, Toyota F, Hikishima K, Nomura T, Funakoshi H, Nakamura T, Aoki M, Toyama Y, Okano H, Nakamura M
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice2011
Author(s)
Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Yamanaka S, Nakamura M, Okano H
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Journal Title
Proc Natl Acad Sci U S A
Volume: 108(40)
Pages: 16825-30
Related Report
Peer Reviewed
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[Presentation] In vino Myelin map based on non-Gaussian diffusion distribution elucidated remyelination after cell transplantation in spinal cord injury primates2012
Author(s)
Kanehiro Fujiyoshi, Tsunehiko Konomi, Osahiko Tsuji, Keigo Hikishima, Akio Iwanami, Morio Matsumoto, Hideyuki Okano, Yoshiaki Toyama, Kazuhiro Chiba, Masaya Nakamura
Organizer
3^<rd> Annual Meeting of Cervical Spine Research Society, Asia Pacific Section
Place of Presentation
Fukuoka
Related Report
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[Presentation] QSIの脊髄再生医療への応用2011
Author(s)
藤吉兼浩,疋島啓吾,百島祐貴,小牧裕司,山田雅之,八木一夫,許斐恒彦,辻収彦,戸山芳昭,岡野栄之,中村雅也
Organizer
第39回日本磁気共鳴医学会大会「Q space imaging/diffusional kurtosis imaging」
Place of Presentation
福岡
Year and Date
2011-09-29
Related Report
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[Presentation] QSIの脊髄再生医療への応用2011
Author(s)
藤吉兼浩, 疋島啓吾, 百島祐貴, 小牧裕司, 山田雅之, 八木一夫, 許斐恒彦, 辻収彦, 戸山芳昭, 岡野栄之, 中村雅也
Organizer
第3S回日本磁気共鳴医学会大会
Place of Presentation
福岡
Year and Date
2011-09-29
Related Report
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