Molecular mechanism of bone metabolism regulated by ubiquitin C-terminal hydrolase-L3

Research Project

Project/Area Number	22791403
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthopaedic surgery
Research Institution	Keio University
Principal Investigator	SUNAMURA Satoko 慶應義塾大学, 医学部, 特任助教 (20570386)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	骨 / 軟骨代謝 / 骨代謝 / 脱ユビキチン化酵素 / 骨芽細胞 / 破骨細胞 / 分化
Research Abstract	Ubiquitin C-terminal hydrolase-L3 deletion mice have high bone mass phenotype. Alkaline phosphatase activity was reduced in the UCH-L3 overexpressed osteoblast. No effect on osteoclast markers was found in UCH-L3 overexpressed osteoclast.

Report

(3 results)