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Molecular mechanism of bone metabolism regulated by ubiquitin C-terminal hydrolase-L3

Research Project

Project/Area Number 22791403
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKeio University

Principal Investigator

SUNAMURA Satoko  慶應義塾大学, 医学部, 特任助教 (20570386)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨 / 軟骨代謝 / 骨代謝 / 脱ユビキチン化酵素 / 骨芽細胞 / 破骨細胞 / 分化
Research Abstract

Ubiquitin C-terminal hydrolase-L3 deletion mice have high bone mass phenotype. Alkaline phosphatase activity was reduced in the UCH-L3 overexpressed osteoblast. No effect on osteoclast markers was found in UCH-L3 overexpressed osteoclast.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (1 results)

All 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Vitamin E decreases bone mass by stimulating osteoclast fusion2012

    • Author(s)
      Fujita K, Sunamura S, Takeda S
    • Journal Title

      Nat. Med

      Volume: 18(4) Pages: 589-594

    • Related Report
      2011 Final Research Report
    • Peer Reviewed

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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