Molecular mechanism of cartilage degradation in human osteoarthritis
| Project/Area Number |
22791407
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
SAWAJI Yasunobu 東京医科大学, 医学部, ポストドクター (20571152)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 軟骨代謝 / 細胞外基質分解酵素 / 細胞内情報伝達 / 細胞・組織 / 酵素 |
|---|
| Research Abstract |
Although ADAMTS-4 and-5 have been identified as important enzymes for development of osteoarthritis(OA), their regulation has been unclear. In this study, we explored and identified intracellular signaling pathways that lead either stimulatory or inhibitory for the expression of these enzymes in human articular cartilage explants. These results may contribute to the development of new drugs that target cartilage degeneration in human OA.
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Report
(3 results)
Research Products
(5 results)
