Development of functional MRI for mechanism of a spinal cord injur

• Project/Area Number: 22791410
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Central Institute for Experimental Animals
• Principal Investigator: KOMAKI Yuji 公益財団法人実験動物中央研究所, 研究員 (10548499)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 脊椎脊髄病学 / functional / MRI / functional MRI / 神経科学 / 脳・神経 / 脳神経疾患 / 再生医学 / 可視化

Research Abstract

Allodynia is one of the essential problem for treatment with transplantation and reproduction in the central nervous system. In this study, we observed neural activity of allodynia using functional MRI and established a method for objective evaluation. This method contributes to clarification of a mechanism of central nervous system for neuropathic pain and leads to develop a novel treatment approach involving pain care.

Research Products

• [Presentation] functional MRI with specific frequency stimulations in mice (2012)
  • Author(s): Komaki Y, Hikishima K, Konomi T, Shibata S, Yamada M, Miyasaka N, Fujiyoshi K, Yagi K, Tamaoki N, Nakamura M, Okano J H, Okano H
  • Organizer: ESMRMB 2012 Congress
  • Place of Presentation: Lisbon, Portugal
• [Presentation] マウス脳機能MRIの確立によるMsi2欠損系統のAllodynia解析 (2012)
  • Author(s): 小牧裕司, 疋島啓吾, 許斐恒彦, 芝田晋介, 山田雅之, 宮坂尚幸, 藤吉兼浩, 八木一夫, 玉置憲一, 百島祐貴, 中村雅也, 岡野J洋尚, 岡野栄之
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
• [Presentation] functional MRI with specific frequency stimulations in allodynia model mice (2012)
  • Author(s): Komaki Y, Hikishima K, Konomi T, Shibata S, Yamada M, Miyasaka N, Fujiyoshi K, Yagi K, Tamaoki N, Nakamura M, Okano J H, Okano H
  • Organizer: APRU-BMAP2012/FIRST2012 Symposia
  • Place of Presentation: Tokyo, Japan
• [Presentation] functional MRI with specific frequency stimulations in allodynia model mice (2012)
  • Author(s): Komaki Yuji
  • Organizer: APRU-BMAP2012/FIRST2012 Symposia
  • Place of Presentation: 東京
• [Presentation] 慢性疼痛モデルマウスにおける神経線維選択的刺激を用いた痛みの可視化解析 (2011)
  • Author(s): 小牧裕司
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: リーガロイヤルホテル(福岡県)
  • Year and Date: 2011-09-29
• [Presentation] 慢性疼痛モデルマウスにおける神経線維選択的刺激を用いた痛みの可視化解析 (2011)
  • Author(s): 小牧裕司, 疋島啓吾, 許斐恒彦, 山田雅之, 宮坂尚幸, 八木一夫, 玉置憲一, 中村雅也, 岡野栄之
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 北九州