| Project/Area Number |
22791413
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
|
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| Research Institution | Yamagata University |
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Principal Investigator |
OTAKI Kei 山形大学, 医学部, 助教 (60572980)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
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| Keywords | セボフルラン / コメットアッセイ / 麻酔科医師 / 慢性毒性 / 作業環境 / 作業管理 |
|---|
| Research Abstract |
The alkaline comet assay was performed for detecting genotoxicity. There were no differences in the DNA damage of the peripheral lymphocytes between anesthesiologists and nonexposed control group. We found that endotracheal tube cuff pressure monitoring was decreased DNA damage significantly. However, it wasn't detected that chronic occupational exposure to sevoflurane and inhalation anesthetics caused DNA damage.
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