Chronic morphine treatment and angiogenesis

• Project/Area Number: 22791423
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Shinshu University
• Principal Investigator: ISHIDA Takashi 信州大学, 医学部・附属病院, 特任研究員 (60531952)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: オピオイド / 腫瘍増大 / 血管新生 / CGRP / アドレノメデュリン / 長期投与

Research Abstract

Chronic treatment of morphine at low doses(0. 1-3mg/kg/day) attenuated the growth of Lewis lung carcinoma(LLC) in C57BL/6 mice. However, higher dose(10mg/kg/day) of morphine does not affect LLC growth. These results suggest that effects of chronic morphine treatment on growth of LLC may be biphasic alteration.

Research Products

• [Journal Article] 産科出血に対する自己血回収装置の使用について (2011)
  • Author(s): 田尻治, 石田高志, 川真田樹人
  • Journal Title: 臨床麻酔 Volume: 35 Pages: 713-716
  • Peer Reviewed
• [Presentation] Efficacy and Safety of Transversus Abdominis Plane Block with Levobupivacaine for gynecologic surgery (2011)
  • Author(s): Ishida T, Tanaka S, Tanaka H, Kawamata M
  • Organizer: Anesthesiology
• [Presentation] Plasma concentration of Levo bupivacaine after Transversus Abdominis Plane Block (2010)
  • Author(s): Ishida T, Tanaka S, Kawamata M
  • Organizer: Anesthesiology
• [Presentation] Plasma Concentration of Levobupivacaine after Transversus Abdominis Plane Block (2010)
  • Author(s): Ishida T, et al.
  • Organizer: American Society of Anesthesiologists
  • Place of Presentation: San Diego, USA.
• [Book] Awake Craniotomyの麻酔.麻酔科研修ノート (2010)
  • Author(s): 石田高志,川真田樹人,稲田英一, 他
  • Publisher: 診断と治療社
• [Book] 麻酔科研修ノート(稲田英一他編)(東京,診断と治療社) (2010)
  • Author(s): 石田高志, 川真田樹人
  • Total Pages: 2
  • Publisher: Awake Craniotomyの麻酔