Chronic morphine treatment and angiogenesis
Project/Area Number |
22791423
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Anesthesiology/Resuscitation studies
|
Research Institution | Shinshu University |
Principal Investigator |
ISHIDA Takashi 信州大学, 医学部・附属病院, 特任研究員 (60531952)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | オピオイド / 腫瘍増大 / 血管新生 / CGRP / アドレノメデュリン / 長期投与 |
Research Abstract |
Chronic treatment of morphine at low doses(0. 1-3mg/kg/day) attenuated the growth of Lewis lung carcinoma(LLC) in C57BL/6 mice. However, higher dose(10mg/kg/day) of morphine does not affect LLC growth. These results suggest that effects of chronic morphine treatment on growth of LLC may be biphasic alteration.
|
Report
(3 results)
Research Products
(6 results)