| Project/Area Number |
22791426
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
KOJIMA Akiko 滋賀医科大学, 医学部, 助教 (50447877)
|
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| Research Collaborator |
MATSUURA Hiroshi 滋賀医科大学, 医学部, 教授 (60238962)
OMATSU Mariko 滋賀医科大学, 医学部, 准教授 (80161397)
KITAGAWA Hirotoshi 滋賀医科大学, 医学部, 講師 (50252391)
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|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 麻酔学 / Ca^<2+>パラドックス / TRPCチャネル |
|---|
| Research Abstract |
Ca^<2+> paradox occurs when the extracellular Ca^<2+> is repleted following Ca^<2+> depletion and is characterized by the intracellular Ca^<2+> overload associated with cellular hypercontracture. We revealed that Ca^<2+> entry via the transient receptor potential canonical(TRPC) channel activated by Ca^<2+> decrease in sarcoplasmic reticulum is responsible for the Ca^<2+> paradox in mouse ventricular myocytes. Furthermore, we found that volatile anesthetic sevoflurane markedly inhibits Ca^<2+> influx through the TRPC channel and thereby protects ventricular myocytes from Ca^<2+> paradox-mediated Ca^<2+> overload.
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