Elucidation of the relation between mu opioid receptor internalization and analgesia induced by oxycodone
| Project/Area Number |
22791432
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | オキシコドン / 体性痛 / 内臓痛 / μオピオイド受容体 / 受容体細胞内陥入 |
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| Research Abstract |
Intrathecal oxycodone produced analgesic effect with induction of mu opioid receptor internalization in vivo. Intrathecal administration of oxycodone showed lower antinociceptive efficacy in somatic and visceral pain compared with subcutaneous administration.
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Report
(3 results)
Research Products
(1 results)
