Elucidation of the relation between mu opioid receptor internalization and analgesia induced by oxycodone

Research Project

Project/Area Number	22791432
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Shimane University
Principal Investigator	HASHIMOTO Tatsuya 島根大学, 医学部, 講師 (00372681)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	オキシコドン / 体性痛 / 内臓痛 / μオピオイド受容体 / 受容体細胞内陥入
Research Abstract	Intrathecal oxycodone produced analgesic effect with induction of mu opioid receptor internalization in vivo. Intrathecal administration of oxycodone showed lower antinociceptive efficacy in somatic and visceral pain compared with subcutaneous administration.

Report

(3 results)