| Project/Area Number |
22791436
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kochi University |
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Principal Investigator |
KAWANO Takashi 高知大学, 教育研究部・医療学系, 講師 (40380076)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | Kイオンチャネル / 神経因性疼痛 / 後根神経節 / 神経ステロイド / 神経障害性痛 / Allopregnanolone / パッチクランプ法 / 核膜 / コンダクタンス / カリウムイオンチャネル / 一次知覚ニューロン / 神経障害性疼痛 / 免疫組織染色 / 疼痛モデル / 単一チャネルコンダクタンス |
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| Research Abstract |
Although detailed mechanisms of neuropathic pain remained unclear, altered sensory function contributes to the pathogenesis of neuropathic pain via hyperexcitability in injured axons. Here, we investigated the analgesic effect to the neuropathic pain targeting ATP-sensitive potassium(K_<ATP>) channels. Our results indicated that reduced K_ATP currents may be a factor in generating neuropathic pain through increased excitability. In addition, we examined the possibility of neurosteroid as the endogenous factor which can modulate K_ATP channel activity. Our results demonstrated that allopregnanolone, one of the neurosteroid, contributed to the pathogenesis of neuropathic pain.
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