Role of the O-linkedβ-N-acetylglucosamine in the Cardioprotection Induced by Isoflurane

• Project/Area Number: 22791437
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: The University of Tokushima
• Principal Investigator: HIROSE Kayo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 特別研究員 (40532221)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 周術期管理学 / 心保護 / 吸入麻酔薬 / 糖鎖 / ミトコンドリア

Research Abstract

Isoflurane induced O-GlcNAc modification mitochondrial protein known as the VDAC. This inhibits the opening of mPTP and results in the acquisition of resistance to ischemia reperfusion stress.

Research Products

• [Journal Article] Role of the O-linkedβ-N-acetylglucosamine in the Cardioprotection Induced by Isoflurane (2011)
  • Author(s): Hirose K, Tsutsumi YM, Tsutsumi R, Shono M, Katayama E, Kinoshita M, Tanaka K, Oshita S.
  • Journal Title: Anesthesiology Volume: 115 Pages: 955-62
  • Peer Reviewed
• [Journal Article] Role of the O-linked β-N-acetylglucosamine in the Cardioprotection Induced by Isoflurane (2011)
  • Author(s): Kayo Hirose
  • Journal Title: Anesthesiology Volume: 115 Pages: 955-62
  • NAID: 40019497531
  • Peer Reviewed
• [Presentation] The Relation Between Isoflurane-induced O-Linkedβ-N-Acetylglucosamine and Mitochondrial Function (2011)
  • Author(s): Kayo Hirose
  • Organizer: American Society of Anesthesiologists Annual Meeting 2011
  • Place of Presentation: 米国シカゴ
  • Year and Date: 2011-10-16
• [Presentation] Isoflurane-induced O-Linkedβ-N-Acetylglucosamine and Mitochondrial Function (2011)
  • Author(s): 廣瀬佳代
  • Organizer: American Society of Anesthesiologists Annual Meeting 2011
  • Place of Presentation: McCormic Center(シカゴ)
  • Year and Date: 2011-10-16
• [Presentation] イソフルランによる心筋保護効果におけるO-Linkedβ-N-Acetylglucosamineとミトコンドリア機能 (2011)
  • Author(s): 廣瀬佳代
  • Organizer: 日本麻酔科学会
  • Place of Presentation: 神戸(神戸国際展示場)
  • Year and Date: 2011-05-19
• [Presentation] イソフルランによる心保護効果におけるO-Linkedβ-N-Acetylglucosamineとミトコンドリア機能 (2011)
  • Author(s): 廣瀬佳代
  • Organizer: 日本麻酔科学会第58回学術集会
  • Place of Presentation: 神戸ポートピアホテル・神戸国際展示場(神戸市)
  • Year and Date: 2011-05-19
• [Presentation] The role of O-linked[ beta]-N-acetylglucosamine in the cardiac protection induced by isoflurane (2010)
  • Author(s): Kayo Hirose
  • Organizer: American Society of Anesthesiologists Annual Meeting 2010
  • Place of Presentation: 米国サンディエゴ
  • Year and Date: 2010-10-16
• [Presentation] The role of O-linked [beta]-N-acetylglucosamine in the cardiac protection induced by isoflurane (2010)
  • Author(s): 廣瀬佳代
  • Organizer: American Society of Anesthesiologists Annual Meeting 2010
  • Place of Presentation: アメリカ合衆国サンディエゴ
  • Year and Date: 2010-10-16
• [Presentation] イソフルランによる心筋保護効果におけるO-Linkedβ-N-Acetylglucosamineの役割 (2010)
  • Author(s): 廣瀬佳代
  • Organizer: 日本麻酔科学会
  • Place of Presentation: 福岡(福岡国際会議場)
  • Year and Date: 2010-06-03
• [Presentation] Role of O-linked-N-acetylglucosamine in isoflurane induced cardiac protection (2010)
  • Author(s): Yasuo Tsutsumi
  • Organizer: Experimental Biology Annual Meetin
  • Place of Presentation: 米国アナハイム
  • Year and Date: 2010-04-06