Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine

• Project/Area Number: 22791440
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nagasaki University
• Principal Investigator: SHIBATA Itsuko 長崎大学, 大学病院, 助教 (10404245)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 心筋虚血再灌流障害 / 心筋スタニング / 強心薬 / PDEIII阻害剤 / p38MAPK / カルシウム感受性増強作用薬 / 薬理学的ポストコンディショニング / 心筋虚血再潅流障害

Research Abstract

We assessed the effect of milrinone application timing after reperfusion against myocardial stunning as compared with levosimendan in swine. Furthermore, we examined the role of p38 mitogen-activated protein kinase (p38 MAPK) in the milrinone-induced cardioprotection. Milrinone should be administered just after reperfusion to protect myocardial stunning through p38 MAPK, whereas levosimendan improvement of contractile function could be mainly dependent on its positive inotropic effect

Research Products

• [Journal Article] Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine (2013)
  • Author(s): Shibata I, Cho S, Yoshitomi O, Ureshino H, Maekawa T, Hara T, Sumikawa K
  • Journal Title: Scand Cardiovasc J Volume: 47 Pages: 50-7
  • NAID: 120006985770
  • Peer Reviewed
• [Journal Article] Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine. (2013)
  • Author(s): Shibata Itsuko
  • Journal Title: Scand Cardiovasc J. Volume: 47 Issue: 1 Pages: 50-57
  • DOI: 10.3109/14017431.2012.732236
  • NAID: 120006985770
  • Peer Reviewed
• [Journal Article] Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs (2012)
  • Author(s): Yoshitomi O, Cho S, Hara T, Shibata I, Maekawa T, Ureshino H, Sumikawa K
  • Journal Title: Shock Volume: 38 Pages: 92-7
  • NAID: 120006985371
  • Peer Reviewed
• [Journal Article] Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine (2012)
  • Author(s): Sakai K, Cho S, Shibata I, Yoshitomi O, Maekawa T, Sumikawa K
  • Journal Title: Scand Cardiovasc J Volume: 46 Pages: 183-9
  • NAID: 120006985409
  • Peer Reviewed
• [Journal Article] Fasudil administered during early reperfusion protects against myocardial infarction through activation of PI3K/Akt/NOS pathway in rats (2012)
  • Author(s): Maekawa T, Cho S, Ichinomiya T, TosakaS, Matsumoto S, Shibata I, Hara T, Sumikawa K
  • Journal Title: 循環制御 Volume: 33 Pages: 96-103
  • NAID: 130004801373
  • Peer Reviewed
• [Journal Article] Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs. (2012)
  • Author(s): Yoshitomi Osamu
  • Journal Title: Shock Volume: 38 Issue: 1 Pages: 92-97
  • DOI: 10.1097/shk.0b013e318254d3fb
  • Peer Reviewed
• [Journal Article] Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine (2011)
  • Author(s): Sakai Kazuyuki
  • Journal Title: Scand Cardiovasc J Volume: 46 Issue: 3 Pages: 183-188
  • DOI: 10.3109/14017431.2012.659676
  • Peer Reviewed
• [Presentation] 右室梗塞に対し右室補助人工心臓を装着し救命しえた一例 (2012)
  • Author(s): 柴田伊津子
  • Organizer: 第12回麻酔科学ウィンターセミナー
  • Place of Presentation: 北海道
• [Presentation] 右室梗塞に対し右室補助人工心臓を装着し救命しえた一例 (2012)
  • Author(s): 柴田伊津子
  • Organizer: 第12回麻酔科学ウインターセミナー
  • Place of Presentation: 北海道
• [Presentation] A p38 MAPK inhibitor, SB203580, blocks cardioprotective effect of post-ischemic administration of milrinone against myocardial stunning in swine (2010)
  • Author(s): Itsuko Shibata
  • Organizer: American Society of anesthesiologists annual meeting 2011
  • Place of Presentation: San Diego(U.S.A.)
• [Presentation] ホスホジエステラーゼ阻害薬ミルリノンとカルシウム感受性増強薬レボシメンダンの投与時期が心筋スタニングの回復に与える影響について (2010)
  • Author(s): 柴田伊津子
  • Organizer: 日本麻酔科学会第56回学術集会
  • Place of Presentation: 福岡市
• [Presentation] Administration of the levosimendan 20-min after Reperfusion Improves Stunned Myocardium in Swine (2010)
  • Author(s): Itsuko Shibata
  • Organizer: 13th Asian Australasian Congress of Anesthesiologists
  • Place of Presentation: Fukuoka(Japan)
• [Presentation] Administration of the levosimendan 20-min after Reperfusion Improves Stunned Myocardium in Swine. (2010)
  • Author(s): Itsuko Shibata
  • Organizer: 13^<th> Asian Australasian Congress of Anesthesiologists
  • Place of Presentation: Fukuoka
• [Presentation] A p38 MAPK inhibitor, SB203580, blocks cardioprotective effect of post-ischemic administration of milrinone against myocardial stunning in swine. (2010)
  • Author(s): Itsuko Shibata
  • Organizer: American Society of anesthesiologists annual meeting 2011
  • Place of Presentation: San Diego U.S.A.
• [Book] 麻酔前の評価・準備と予後予測 (2012)
  • Author(s): 柴田伊津子、澄川耕二
  • Publisher: 克誠堂出版
• [Book] 麻酔前の評価・準備と予後予測 (2012)
  • Author(s): 柴田 伊津子
  • Total Pages: 6
  • Publisher: 克誠堂出版
• [Book] IV.循環薬理 周術期循環管理 (2011)
  • Author(s): 村田寛明、柴田伊津子、澄川耕二
  • Publisher: 克誠堂出版
• [Book] IV.循環薬理周術期循環管理 (2011)
  • Author(s): 村田寛明、柴田伊津子、澄川耕二
  • Publisher: 克誠堂出版