The development of pharmacological postconditioning in diabetes rats and the elucidation of the molecular mechanism

• Project/Area Number: 22791442
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nagasaki University
• Principal Investigator: ICHINOMIYA Taiga 長崎大学, 大学病院, 助教 (50404249)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 薬理学的ポストコンディショニング / 塩酸ファスジル / 糖尿病 / 耐糖能異常

Research Abstract

Fasudil induces PostC against myocardial infarction via activation of m-KATP channels in the rat. Although hyperglycemia attenuates the PostC, high-dose fasudil can restorecardioprotection.

Research Products

• [Journal Article] High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels (2012)
  • Author(s): Taiga Ichinomiya, Sungsam Cho, Ushio Higashijima, Shuhei Matsumoto, Takuji Maekawa, Koji Sumikawa
  • Journal Title: Cardiovasc Diabetol Volume: 11(1) Issue: 1 Pages: 28-28
  • DOI: 10.1186/1475-2840-11-28
  • NAID: 120006985422
  • Peer Reviewed
• [Presentation] 塩酸ファスジルによる心筋ポストコンディショニング効果の分子細胞機構 (2013)
  • Author(s): 一ノ宮 大雅
  • Organizer: 循環制御
  • Place of Presentation: 福井
• [Presentation] High-dose fasudil preservespostconditioning against myocardial infarction under hyperglycemia inrats:role of mitochondrial KATP channels (2012)
  • Author(s): Koji Sumikawa、Taiga Ichinomiya、et al
  • Organizer: World Congress of Anesthesiologists
  • Place of Presentation: トルコ
  • Year and Date: 2012-04-22
• [Presentation] High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats:role of mitochondrial KATP channels (2012)
  • Author(s): KOJI SUMIKAWA
  • Organizer: World Congress of Anesthesiologists
  • Place of Presentation: Istanbul
• [Presentation] 急性高血糖ラット心筋虚血モデルにおける塩酸ファスジルの心筋ポストコンディショニング効果 (2011)
  • Author(s): 一ノ宮大雅
  • Organizer: 日本集中治療医学会総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-02-25
• [Presentation] 塩酸ファスジルの心ポストコンディショニング効果-再灌流後の投与時期による影響と保護機序に関する検討- (2010)
  • Author(s): 一ノ宮大雅
  • Organizer: 日本麻酔科学会総会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2010-06-04
• [Presentation] 急性高血糖ラット心筋虚血モデルにおける塩酸ファスジルの心筋ポストコンディショニング効果 (2010)
  • Author(s): 一ノ宮大雅 他
  • Organizer: 日本集中治療医学会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-05