| Project/Area Number |
22791448
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagoya City University |
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Principal Investigator |
SOU Mine 名古屋市立大学, 大学院・医学研究科, 助教 (60381886)
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| Co-Investigator(Renkei-kenkyūsha) |
ASAI Kiyofumi 名古屋市立大学, 大学院・医学研究科, 教授 (70212462)
SOBUE Kazuya 名古屋市立大学, 大学院・医学研究科, 教授 (90264738)
ARIMA Hajime 名古屋市立大学, 大学院・医学研究科, 講師 (20254295)
HIRATE Hiroyuki 名古屋市立大学, 大学院・医学研究科, 助教 (20363939)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 蘇生学 / 蘇生 / 水チャネル / 脳浮腫 |
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| Research Abstract |
Astrocytic swelling is one of the mechanisms of brain edema. We found that AQP4 enhanced expression which rose by ischemia-reoxygenation relates to astrocytic swelling. Participation of AQP4 was suggested to the cerebral edema by brain ischemia in an animal model. When astrocyte was medicated with the inhibitory drug(SN-50) of NF-kB, or the inhibitory drug(SB203580)of p38 MAPK and ischemia-reoxygenation was caused, the tendency for the rapid revelation rise of AQP4 to be controlled was acquired. Although the further examination was required, a possibility that regulation of cerebral edema could be performed by this research was suggested.
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