Elucidation of the monoamine dynamics at the descending pain modulation system in the diabetic neuropathy model rat

• Project/Area Number: 22791451
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Osaka City University
• Principal Investigator: 友晴 Tomoharu 大阪市立大学, 大学院・医学研究科, 講師 (70433307)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 糖尿病性神経障害 / 下行性疼痛抑制系 / 脳内モノアミン

Research Abstract

We investigated the correlation between NA release in the LC and efficacy of morphine, tramadol, and clomipramine in rats with diabetic mellitus (DM).In the morphine group, NA release in the LC was not significantly correlated with the pain threshold. In

Research Products

• [Journal Article] Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy (2013)
  • Author(s): Koichi Suehiro, Tomoharu Funao, Yohei Fujimoto, Tokuhiro Yamada, Takashi Mori, Kiyonobu Nishikawa.
  • Journal Title: Life Sciences Volume: 92(23) Issue: 23 Pages: 1138-44
  • DOI: 10.1016/j.lfs.2013.04.015
  • Peer Reviewed
• [Journal Article] Systemic vascular resistance has an impact on the reliability of the Vigileo-FloTrac system in measuring cardiac output and tracking cardiac output changes (2013)
  • Author(s): Koichi Suehiro
  • Journal Title: British Journal of Anaesthesia Volume: 110 Issue: 2 Pages: 1-8
  • DOI: 10.1093/bja/aet022
  • Peer Reviewed
• [Journal Article] ガンマナイフ後に再発した三叉神経痛4症例に対する治療法の検討 (2011)
  • Author(s): 萩原千恵, 他
  • Journal Title: ペインクリニック Volume: 32 Pages: 1225-1229
  • Peer Reviewed
• [Journal Article] Intrathecal gabapentin and clonidine synergistically inhibit allodynia in spinal nerve-ligated rats (2010)
  • Author(s): Yoshihiro Yamama, et al.
  • Journal Title: Life Science Volume: 87 Pages: 565-571
  • Peer Reviewed
• [Journal Article] くも膜下フェノールブロックと仙骨部神経根高周波熱凝固術が著効した旧肛門部痛の1例 (2010)
  • Author(s): 舟尾友晴, 他
  • Journal Title: Palliative Care Research Volume: 5 Pages: 314-316
  • NAID: 130000301675
  • Peer Reviewed
• [Journal Article] 術中心停止を来した慢性3枝ブロックの1症例 (2010)
  • Author(s): 堀耕太郎, 他
  • Journal Title: 麻酔 Volume: 59 Pages: 206-209
  • Peer Reviewed
• [Presentation] Noradrenaline release in the locus coeruleus of streptozotocin-induced diabetic rats: a microdialysis study (2012)
  • Author(s): Koichi Suehiro, Tomoharu Funao, Katsuaki Tanaka, Takashi Mori, Kiyonobu Nishikawa
  • Organizer: American society of anesthesiologists
  • Place of Presentation: Washington DC,USA
  • Year and Date: 2012-10-13
• [Presentation] Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy (2012)
  • Author(s): Koichi Suehiro
  • Organizer: American society of anesthesiologists
  • Place of Presentation: Walter E. Washington Convention Center, Washington, DC, USA.
• [Presentation] The impact of intraoperative hypothermia on early postoperative adverse events after esophagectomy (2012)
  • Author(s): Hiroyuki Yamasaki
  • Organizer: American society of anesthesiologists
  • Place of Presentation: Walter E. Washington Convention Center, Washington, DC, USA.
• [Presentation] Influence of Systemic Vascular Resistance on the Accuracy of Cardiac Output and Tracking Changes in Vigileo-Flotrac System (2012)
  • Author(s): Koichi Suehiro
  • Organizer: American society of anesthesiologists
  • Place of Presentation: Walter E. Washington Convention Center, Washington, DC, USA.
• [Presentation] 硬膜外穿刺におけるフェンタニル補助投与の有効性について (2011)
  • Author(s): 清水雅子, 他
  • Organizer: 日本麻酔科学会
  • Place of Presentation: 兵庫県,神戸国際会議場
  • Year and Date: 2011-05-20
• [Presentation] 区域麻酔の合併症 (2010)
  • Author(s): 舟尾友晴
  • Organizer: 第57回日本麻酔科学会
  • Place of Presentation: 福岡県、福岡国際会議場(招待講演)
  • Year and Date: 2010-06-05