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Elucidation of the monoamine dynamics at the descending pain modulation system in the diabetic neuropathy model rat

Research Project

Project/Area Number 22791451
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOsaka City University

Principal Investigator

友晴 Tomoharu  大阪市立大学, 大学院・医学研究科, 講師 (70433307)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords糖尿病性神経障害 / 下行性疼痛抑制系 / 脳内モノアミン
Research Abstract

We investigated the correlation between NA release in the LC and efficacy of morphine, tramadol, and clomipramine in rats with diabetic mellitus (DM).In the morphine group, NA release in the LC was not significantly correlated with the pain threshold. In

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2013 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results)

  • [Journal Article] Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy2013

    • Author(s)
      Koichi Suehiro, Tomoharu Funao, Yohei Fujimoto, Tokuhiro Yamada, Takashi Mori, Kiyonobu Nishikawa.
    • Journal Title

      Life Sciences

      Volume: 92(23) Issue: 23 Pages: 1138-44

    • DOI

      10.1016/j.lfs.2013.04.015

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Systemic vascular resistance has an impact on the reliability of the Vigileo-FloTrac system in measuring cardiac output and tracking cardiac output changes2013

    • Author(s)
      Koichi Suehiro
    • Journal Title

      British Journal of Anaesthesia

      Volume: 110 Issue: 2 Pages: 1-8

    • DOI

      10.1093/bja/aet022

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ガンマナイフ後に再発した三叉神経痛4症例に対する治療法の検討2011

    • Author(s)
      萩原千恵, 他
    • Journal Title

      ペインクリニック

      Volume: 32 Pages: 1225-1229

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrathecal gabapentin and clonidine synergistically inhibit allodynia in spinal nerve-ligated rats2010

    • Author(s)
      Yoshihiro Yamama, et al.
    • Journal Title

      Life Science

      Volume: 87 Pages: 565-571

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] くも膜下フェノールブロックと仙骨部神経根高周波熱凝固術が著効した旧肛門部痛の1例2010

    • Author(s)
      舟尾友晴, 他
    • Journal Title

      Palliative Care Research

      Volume: 5 Pages: 314-316

    • NAID

      130000301675

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 術中心停止を来した慢性3枝ブロックの1症例2010

    • Author(s)
      堀耕太郎, 他
    • Journal Title

      麻酔

      Volume: 59 Pages: 206-209

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Noradrenaline release in the locus coeruleus of streptozotocin-induced diabetic rats: a microdialysis study2012

    • Author(s)
      Koichi Suehiro, Tomoharu Funao, Katsuaki Tanaka, Takashi Mori, Kiyonobu Nishikawa
    • Organizer
      American society of anesthesiologists
    • Place of Presentation
      Washington DC,USA
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy2012

    • Author(s)
      Koichi Suehiro
    • Organizer
      American society of anesthesiologists
    • Place of Presentation
      Walter E. Washington Convention Center, Washington, DC, USA.
    • Related Report
      2012 Annual Research Report
  • [Presentation] The impact of intraoperative hypothermia on early postoperative adverse events after esophagectomy2012

    • Author(s)
      Hiroyuki Yamasaki
    • Organizer
      American society of anesthesiologists
    • Place of Presentation
      Walter E. Washington Convention Center, Washington, DC, USA.
    • Related Report
      2012 Annual Research Report
  • [Presentation] Influence of Systemic Vascular Resistance on the Accuracy of Cardiac Output and Tracking Changes in Vigileo-Flotrac System2012

    • Author(s)
      Koichi Suehiro
    • Organizer
      American society of anesthesiologists
    • Place of Presentation
      Walter E. Washington Convention Center, Washington, DC, USA.
    • Related Report
      2012 Annual Research Report
  • [Presentation] 硬膜外穿刺におけるフェンタニル補助投与の有効性について2011

    • Author(s)
      清水雅子, 他
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      兵庫県,神戸国際会議場
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 区域麻酔の合併症2010

    • Author(s)
      舟尾友晴
    • Organizer
      第57回日本麻酔科学会
    • Place of Presentation
      福岡県、福岡国際会議場(招待講演)
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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