| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Research Abstract |
The role of glutamate receptors in descending pain modulation after noxious is unclear. In an animal model of acute and tonic nociception, we examined the effects of intracerebroventricular administration of AMPA receptor antagonist, with/without NMDA receptor agonist. Intracerebroventricular administration of YM 872, AMPA antagonist, significantly and dose-dependently decreased the number of flinches in both early and late phase of the formalin test without abnormal motor function. Intracerebroventricular administration of YM872 with D-serine, an endogenous and obligatory co-agonist for the NMDA receptor glycine site, decreased significantly and dose-dependently the number of flinches in both early and late phase of the formalin test. These results suggest that the inhibition of AMPA receptors and activation of NMDA receptor at the supraspinal level could induce the antinociceptive effects.
|
