Novel pathological parameters in regional lymph nodes of urothelial carcinoma focused on "Seed and Soil" theory

• Project/Area Number: 22791462
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Hokkaido University
• Principal Investigator: ABE Takashige 北海道大学, 北海道大学病院, 助教 (10399842)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 尿路上皮癌 / 微小リンパ節転移 / 所属リンパ節 / リンパ管新生 / 尿路上皮がん

Research Abstract

Study 1 : Fifty-one patients treated by nephroureterectomy were included. All had lymph nodes(LNs) and all LNs were negative on hematoxylin and eosin staining. We re-evaluated the presence of micrometastasis in LNs specimens by anti-cytokeratin immunohistochemistory. Immunohistochemistry identified micrometastases in 7(14%) of 51 patients. Study 2 : We prospectively evaluated the presence of micrometastasis in LNs in patients undergoing radical cystectomy or nephroureterectomy. Micrometastasis was detected in 9%(2/22) of patients undergoing radical cystectomy. Study 3 : We evaluated the association between the expression of VEGFC mRNA, VEGFD mRNA, or VEGF3R mRNA and pathological characteristic in primary tumors. We subsequently evaluated the lymph vascular density(LVD) in marginal zone of regional lymph nodes. The expression of VEGFC mRNA was higher in> pT2 disease than<pT1 disease. LVD was higher in patients with node metastasis than patients without it. In addition, the accumulation of lymphatic vessels was observed in half of the cases without node metastases.

Research Products

• [Journal Article] Influence of basel ine renal function and dose reduction of ne phrotoxic chemotherapeutic agents on the o utcome of metastatic urothelial carcinoma a retrospective study (2012)
  • Author(s): Maru S, Abe T, et al
  • Journal Title: Int J Urol Volume: 19 Pages: 1-9
  • NAID: 10031184789
  • Peer Reviewed
• [Journal Article] Influence of baseline renal function and dose reduction of nephrotoxic chemotherapeutic agents on the outcome of metastatic urothelial carcinoma : a retrospective study (2012)
  • Author(s): Maru S, Abe T, Shinohara N, et al.
  • Journal Title: International Journal of Urology Volume: 19 Issue: 2 Pages: 110-116
  • DOI: 10.1111/j.1442-2042.2011.02913.x
  • NAID: 10031184789
  • Peer Reviewed
• [Journal Article] Interferon-α-based immunotherapy in metastatic renal cell carcinoma patients with the primary tumor in situ (2012)
  • Author(s): hinohara N, Abe T, Sazawa A, et al
  • Journal Title: Jpn J Clin Oncol Volume: 42 Issue: 2 Pages: 113-119
  • DOI: 10.1093/jjco/hyr176
  • Peer Reviewed
• [Journal Article] Outcome of regional lymph node dissecti on in conjunction with laparoscopic nephro ureterectomy for urothelial carcinoma of th e upper urinary tract (2011)
  • Author(s): Abe T, Harabayashi T, Shinohara N, et al
  • Journal Title: J Endourol Volume: 25 Pages: 803-7
  • Peer Reviewed
• [Journal Article] Outcome of regional lymph node dissection in conjunction with laparoscopic nephroureterectomy for urothelial carcinoma of the upper urinary tract (2011)
  • Author(s): Abe T, Harabayashi T, Shinohara N, et al.
  • Journal Title: Journal of Endourology Volume: 25 Issue: 5 Pages: 803-807
  • DOI: 10.1089/end.2010.0480
  • Peer Reviewed
• [Journal Article] Is memorial sloan-kettering cancer center risk classification appropriate for japanese patients with metastatic renal cell carcinoma in the cytokine era? (2011)
  • Author(s): Shinohara N, Abe T, Mochizuki T, Kashiwagi A, Kanagawa K, et al.
  • Journal Title: Urologic Oncology Volume: 31 Issue: 7 Pages: 1276-1282
  • DOI: 10.1016/j.urolonc.2011.08.009
  • Peer Reviewed
• [Journal Article] Outcome of Regional Lymph Node Dissection in Conjunction with Laparoscopic Nephroureterectomy for Urothelial Carcinoma of the Upper Urinary Tract. (2011)
  • Author(s): Abe T, Harabayashi T, Shinohara N, Sazawa A, Maruyama S, Sasaki H, Nonomura K.
  • Journal Title: Journal of Endourology Volume: (In press)
  • Peer Reviewed
• [Journal Article] Role of lymph node dissection in the trea tment of urothelial carcinoma of the upper urinary tract : multi-institutional relapse anal ysis and immunohistochemical re-evaluation of negative lymph nodes (2010)
  • Author(s): Abe T, Shinohara N, Muranaka M, et al
  • Journal Title: Eur J Surg On col Volume: 36 Pages: 1085-91
  • Peer Reviewed
• [Journal Article] I mpact of diagnostic ureteroscopy on intrave sical recurrence and survival in patients wit h urothelial carcinoma of the upper urinary tract (2010)
  • Author(s): Ishikawa S, Abe T, Shinohara N, et al
  • Journal Title: J Urol Volume: 184 Pages: 883-7
  • Peer Reviewed
• [Journal Article] Pathological characteristics and clinical course of bladder tumour developing after nephroureterectomy (2010)
  • Author(s): Abe T, Shinohara N, Harabayashi T, et al
  • Journal Title: BJU Int Volume: 105 Pages: 1102-6
  • Peer Reviewed
• [Journal Article] Impact of diagnostic ureteroscopy on intravesical recurrence and survival in patients with urothelial carcinoma of the upper urinary tract. (2010)
  • Author(s): Ishikawa S, Abe T, Shinohara N, Harabayashi T, Sazawa A, Maruyama S, Kubota K, Matsuno Y, Osawa T, Shinno Y, Kumagai A, Togashi M, Matsuda H, Mori T, Nonomura K.
  • Journal Title: Journal of Urology Volume: 184(3) Pages: 883-7
  • Peer Reviewed
• [Journal Article] Role of lymph node dissection in the treatment of urothelial carcinoma of the upper urinary tract : Multi-institutional relapse analysis and immunohistochemical re-evaluation of negative lumph nodes. (2010)
  • Author(s): Abe T, Shinohara N, Muranaka M, Sazawa A, Maruyama S, Osawa T, Harabayashi T, Kubota K, Matsuno Y, Shibata T, Toyoda Y, Shinno Y, Minami K, Sakashita S, Kumagai A, Takada N, Togashi M, Sano H, Mori T, Nonomura K.
  • Journal Title: European Journal of Surgical Oncology Volume: 36 Pages: 1085-1091
  • Peer Reviewed
• [Presentation] 冷却併用腹腔鏡下腎部分切除術 (2011)
  • Author(s): 安部崇重
  • Organizer: 第25回日本泌尿器内視鏡学会総会(招請講演)
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2011-11-30
• [Presentation] 冷却併用腹腔鏡下腎部分切除術 (2011)
  • Author(s): 安部崇重
  • Organizer: 第25回日本泌尿器内視鏡学会総会
  • Place of Presentation: 京都国際会議場(京都)(招請講演)
  • Year and Date: 2011-11-30
• [Presentation] 尿路上皮癌に対する根治的膀胱全摘除術後及び腎尿管全摘除術後の再発の特徴 (2011)
  • Author(s): 安部崇重, 他
  • Organizer: 第49回日本癌治療学会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-10-27
• [Presentation] 膀胱全摘後の遅発性再発について (2011)
  • Author(s): 安部崇重, 他
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-04-21
• [Presentation] 尿路上皮癌clinical node^+症例の治療成績 (2010)
  • Author(s): 安部崇重, 他
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: ホテルメトロポリタン盛岡(盛岡)
  • Year and Date: 2010-04-27
• [Presentation] 尿路上皮癌clinical node+症例の治療成績 (2010)
  • Author(s): 安部崇重、篠原信雄、佐澤陽、丸山覚、原林透、鈴木信、大澤崇宏、丸晋太郎、石川修平、野々村克也
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡
• [Book] こんなときどうする!?泌尿器科手術のトラブル対処法膀胱の手術膀胱全摘除後に閉鎖神経麻痺が出てきた (2011)
  • Author(s): 安部崇重
• [Book] 冷却併用腹腔鏡下腎部分切除術 (2011)
  • Author(s): 安部崇重, 他
  • Publisher: Jpanese Journal of Endourology