| Project/Area Number |
22791465
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 腫瘍学 / 膀胱癌 / RANTES / CCR5 / 尿中サイトカイン |
|---|
| Research Abstract |
We measured the urinary cytokines using ELISA, and found that mean urinary RANTES level were significantly higher than that of healthy control. Immunohistologically, the expression of CCR5, which is main receptor of RANTES, was found in primary bladder tumors. There was a statistically significant association between increased CCR5 expression in tumors and tumor stage or tumor grade. The high grade or high stage tumors had significantly higher expression levels of CCR5.
Our results suggest that the high level of urine RANTES may be a candidate novel marker of the presence of bladder cancer. Furthermore, the increased CCR5 expression in the cytoplasm of bladder cancer cells may be associated with aggressive type of bladder cancer and be a marker for disease progression.
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