The study of the new molecular cancer treatment targeting for apoptosis inhibitor survivin.

• Project/Area Number: 22791466
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Gunma University
• Principal Investigator: KOIKE Hidekazu 群馬大学, 大学院・医学系研究科, 助教 (90420091)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: サバイビン / 前立腺癌 / 腎癌

Research Abstract

We suggested that survivin have significant associations with prostate cancer cell proliferation, plays an essential role in simvastatin induced cell growth inhibition, and plays an essential role in active D3 induced cell growth inhibition in prostate cancer. The elimination of Survivin would be also a potential candidate for a novel approach to treat prostate cancer.
In renal cell cancer, simvastatin has anticancer effect being associated with IGF-1r. Survivin is associated with simvastatin resistance of renal cancer cells.

Research Products

• [Journal Article] Survivin is associated with cell proliferation and has a role in 1a,25-dihydroxyvitamin D3 induced cell growth inhibition in prostate cancer (2011)
  • Author(s): Hidekazu Koike, et al.
  • Journal Title: Journal of Urology Volume: 185 Pages: 1497-1503
  • Peer Reviewed
• [Journal Article] Survivin is associated with cell proliferation and has a role in la,25-dihydroxyvitamin D3 induced cell growth inhibition in prostate cancer (2011)
  • Author(s): Hidekazu Koike
  • Journal Title: Journal of Urology Volume: 185 Pages: 1497-1503
  • Peer Reviewed
• [Presentation] High-fat diet increased renal cancer growth, the antitumor sensitization effect due to survivin inhibition in simvastatin treatment for renal cancer cells (2011)
  • Author(s): Hidekazu Koike, et al.
  • Organizer: 第106回 米国泌尿器科学会年次総会
  • Place of Presentation: アメリカワシントンDC
  • Year and Date: 2011-05-15
• [Presentation] High-fat diet increased renal cancer growth, and the antitumor sensitization effect due to survivin inhibition in simvastatin treatment for renal cancer cells (2011)
  • Author(s): 小池秀和
  • Organizer: 第106回 米国泌尿器科学会年次総会
  • Place of Presentation: アメリカ ワシントンDC
  • Year and Date: 2011-05-15
• [Presentation] 再燃前立腺癌に対するドセタキセル療法の検討 (2011)
  • Author(s): 小池秀和
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-04-23
• [Presentation] 再燃前立腺癌に対するドセタキセル療法の検討 (2011)
  • Author(s): 小池秀和
  • Organizer: 第99回 日本泌尿器科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-04-23
• [Presentation] スタチンのsurvivin抑制による腎癌細胞増殖抑制効果 (2010)
  • Author(s): 小池秀和
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: 京都府、左京区宝ヶ池
  • Year and Date: 2010-10-29
• [Presentation] スタチンのsurvivin抑制による腎癌細胞増殖抑制効果 (2010)
  • Author(s): 小池秀和
  • Organizer: 第48回 日本癌治療学会学術集会
  • Place of Presentation: 京都府、左京区宝ヶ池
  • Year and Date: 2010-10-29
• [Presentation] Statin inhibits the proliferation of human renal cancer cells via down-regulation of the survivin through IGF-1 signaling (2010)
  • Author(s): Hidekazu Koike, et al.
  • Organizer: 第105回米国泌尿器科学会年次総会
  • Place of Presentation: アメリカ、サンフランシスコ
  • Year and Date: 2010-05-30
• [Presentation] Statin inhibits the proliferation of human renal cancer cells via down-regulation of the survivin through IGF-1 signaling. (2010)
  • Author(s): 小池秀和
  • Organizer: 第105回 米国泌尿器科学会年次総会
  • Place of Presentation: アメリカ、サンフランシスコ
  • Year and Date: 2010-05-30
• [Presentation] 前立腺癌細胞におけるビタミンD3 (1α,25(OH)2D3) の抗腫瘍効果とsurvivin発現の関連 (2010)
  • Author(s): 小池秀和
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 岩手県、盛岡市
  • Year and Date: 2010-04-27
• [Presentation] 前立腺癌細胞におけるビタミンD_3(1α,25(OH)_2D_3)の抗腫瘍効果とsurvivin発現の関連 (2010)
  • Author(s): 小池秀和
  • Organizer: 第98回 日本泌尿器科学会総会
  • Place of Presentation: 岩手県、盛岡市
  • Year and Date: 2010-04-27
• [Presentation] Statin inhibits the proliferation of human prostate cancer cells via down-regulation of the survivin (2010)
  • Author(s): Hidekazu Koike, et al.
  • Organizer: 第25回欧州泌尿器科学会年次総会
  • Place of Presentation: スペイン、バルセロナ
  • Year and Date: 2010-04-19
• [Presentation] Statin inhibits the proliferation of human prostate cancer cells via down-regulation of the survivin. (2010)
  • Author(s): 小池秀和
  • Organizer: 第25回 欧州泌尿器科学会年次総会
  • Place of Presentation: スペイン、バルセロナ
  • Year and Date: 2010-04-19