Can GABA agonist improve nocturia symptoms?-basic research to elucidate the relationship between sleep and bladder function

Research Project

Project/Area Number	22791470
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Urology
Research Institution	University of Fukui
Principal Investigator	MATSUTA Yosuke 福井大学, 医学部, 助教 (90345687)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	メラトニン / ゾルピデム / 脳波 / 膀胱 / 睡眠
Research Abstract	Intravenous melatonin administration was found to significantly increase intercontraction interval in 24-month-old rats, however, it did not affect micturition voiding pressure, basal pressure, pressure threshold. It showed no significant changes in 10-week-old rats. Electroencephalographic findings showed that melatonin did not influence relative power values in either group. Melatonin increased bladder capacity without affecting bladder pressure in 24-month-old rats and can therefore be expected to be beneficial for treating nocturia in the elderly.

Report

(3 results)