Can GABA agonist improve nocturia symptoms?-basic research to elucidate the relationship between sleep and bladder function
Project/Area Number |
22791470
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Urology
|
Research Institution | University of Fukui |
Principal Investigator |
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | メラトニン / ゾルピデム / 脳波 / 膀胱 / 睡眠 |
Research Abstract |
Intravenous melatonin administration was found to significantly increase intercontraction interval in 24-month-old rats, however, it did not affect micturition voiding pressure, basal pressure, pressure threshold. It showed no significant changes in 10-week-old rats. Electroencephalographic findings showed that melatonin did not influence relative power values in either group. Melatonin increased bladder capacity without affecting bladder pressure in 24-month-old rats and can therefore be expected to be beneficial for treating nocturia in the elderly.
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Report
(3 results)
Research Products
(2 results)